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Yang Jing, Xu Wen, Zhu Yao, et al
Objective: To evaluate the efficacy and the safety of Marvelon in treating puberty dysfunctional uterine bleeding Methods: Randomized controlled trials (RCTs) which interfered with puberty dysfunctional uterine bleeding by Marvelon in the databases VIP,CNKI and FMJS were searched According to the systemic review methods of Cochrane Library, the quality of methodologies of the involved studies were evaluated before metaanalysis was conducted Results: Ten RCTs involving 555 patients were included-Compared with the therapy of estrogen in combination with progesterone or the therapy of the single reproductive hormone, Marvelon not only significantly increased the total effective rate (OR: 9.19, 95%CI: 3.56, 23.75, P<0.01) and the recovery rate (OR: 3.51, 95%CI: 2.46, 4.99, P<0.01), but also shortened the complete hemostasis time (WMD: 22.76, 95%CI: 26.67, 18.86, P<0.01) While different levels of adverse reactions appeared in both the trial and controlled groups Conclusion: The metaanalysis reveals that in the treatment of puberty dysfunctional uterine bleeding, Marvelon possess certain advantages, such as increasing the total effective rate and the recovery rate as well as shortening the complete hemostasis time-However, this evidence contributes limited sense to the clinical treatment of puberty dysfunctional uterine bleeding due to the quality of involved trails, possible bias risk and no long-term safety evaluation on Marvelon
2014 Vol. 22 (5): 292- [Abstract]（
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Zhang Cuiling, Liu Hongyan, Jiang Yu, et al
Objective: To analyze the proportion of women who has contraindications to their current longterm contraceptive in rural Beijing Methods: Quantitative analysis by using checkup data for women of childbearing age with longterm contraceptive in rural Beijing in year 2008 Based on biochemical test, ultrasound results to determine whether there were contraindications for female longterm contraceptive users, including longterm contraceptive users suffering from high blood pressure, heart disease, stroke, kidney abnormalities, diabetes, hysteromyoma, hyperplasia of mammary glands; and IUD users with pelvic inflammation and adnexitis, vaginitis and cervical; and Norplant users with abnormal liver and kidney function "Unsuitability" was defined as the ratio of number of women with contraindications to their current contraceptive methods among the number of same contraceptive users Results: About 13.33% of the longterm contraceptive users had contraindications to their current methods Long-term oral contraceptives had the highest unsuitability (96.69%), closely followed by subdermal implants (30.86%) The smallest unsuitability was found in IUD users (10.73%) Conclusion: It is recommended to strengthen regular followup and dynamic monitoring for longacting contraception users, especially for highrisk group, and to take appropriate treatment if contraception contraindications are found and help users to transform to alternative appropriate contraceptive in order to improve reproductive health of women of childbearing age
2014 Vol. 22 (5): 296- [Abstract]（
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Guo Yong, He Sen, Su Chen,et al
Objective: To investigate the promoting effect of mifepristone on the apoptosis of human breast cancer cells T47D in vitro. Methods: T47D cells were treated by different concentrations (0.25, 2.5, 25 and 50μmol/L) of mifepristone. Then the apoptosis of these cells was examined by TUNEL assay under the microscope on day 2. The apoptosis was also examined by Annexin V-FITC assay. Results: Compared with the control group, the number and intensities of the TUNEL-positive cells in 25μmol/L group and 50μmol/L group were significantly higher and stronger. The apoptosis rates of 25μmol/L group (16.1±3.5%, P=0.010) and 50μmol/L group (17.2±3.8%, P=0.009) were significantly higher than that of the control group (5.1±2.3%). There were no significant differences between the control group and 0.25μmol/L group (P=0.818) as well as 2.5μmol/L group (P=0.884). Conclusion: Mifepristone can induce the apoptosis of T47D cells in a dose-dependent manner.
2014 Vol. 22 (5): 300- [Abstract]（
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Luo Qianqian, Liu Ranran, Zhang Dongmei, et al
Objective: To explore the expressions and interaction between Kisspeptin/Kiss1r system and gonadotropin-releasing hormone (GnRH) in the hypothalamic arcuate nucleus of rat models with polycystic ovarian syndrome (PCOS). Methods: Pregnant Wistar rats were obtained and their female pups were divided into the control or PCOS groups randomly. Letrozole was used for established models . Body parameters, endocrine hormones and ovarian morphology were measured after modeling. Protein expressions and gene levels of Kisspeptin, Kiss1r and GnRH in the hypothalamic arcuate nucleus were measured with immunohistochemistry, western blot and qRT-PCR. Results: Rat models with the typical endocrine and ovarian changes in PCOS were successfully established. Compared to the controls, the protein expression and gene level of GnRH in the hypothalamic arcuate nucleus of PCOS rats increased significantly (P＜0.01). Expressions of Kisspeptin/Kiss1r system in PCOS rats all decreased (P＜0.01) except the gene level of kiss1r. Conclusion: Down-regulation of Kisspeptin/Kiss1r system and significant increase in GnRH in the hypothalamic arcuate nucleus of PCOS rats, which could be the results of the endocrine disorder, may play an important role in the development of PCOS.
2014 Vol. 22 (5): 304- [Abstract]（
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Zhang Xiaohua, Zhu Haoping, Xiao Liping, et al
Objective: To analyze the influence of reversible contraceptive methods utility on women's postmenopausal health in reproductive system Methods: Women were divided into group I (IUD), group II (oral contraceptives), group III (condom), group IV (tubal ligation) and the contrast group (rhythm method/external ejaculation) Data were collected via local electronic health network Results: A total of 3955 postmenopausal women were recruited (group I=2253, group II=703, group III=508, group IV=202, contrast=289) Pearl Index was 1.08 (group I), 1.62 (group II), 1.91 (group III), 0 (group IV) and 15.22 (contrast group). Logistic regression found body mass index (OR=1.04), pregnancy history (OR=3.24), parous (OR=0.56), reversible contraceptive usage（OR=0.59）and contraception failure（OR=1.83）were associated factors to develop benign diseases of reproductive system in postmenopausal period, and effective reversible contraceptive methods were assumed to reduce the risk by more than 50%. Conclusion: For postmenopausal women, history of applying reversible contraceptive methods could reduce the risk of benign reproductive diseases.
2014 Vol. 22 (5): 309- [Abstract]（
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Huang Dongsheng,Zheng Weibin,Yang Jiafang, et al
Objective: To explore the trend of seroprevalence on human immunodeficiency virus (HIV), awareness of related HIV knowledge, and the feature of risk behavior among pregnant women in Baoshan Prefecture, in order to provide scientific evidence for policy-making of preventing HIV spreading. Methods: The surveillance data of seroprevalence status, awareness of related HIV knowledge, and features of risk behavior on HIV in pregnant women who visited antenatal clinics in Baoshan Prefecture between 2009 and 2011 were collected and analyzed. Results: A total of 1600 pregnant women were included from 2009 to 2011, and the seroprevalences of HIV were 0.13%, 0.25%, and 0.50%, respectively. The awareness of HIV related knowledge was 84.1%, and the results of multivariable logistic regression showed the education level, gestation age, having experience of working outside were risk factors. In terms of a history of drug abuse, the proportions among pregnant women ranged from 2009 to 2011 were 0.13%, 1.25%, and 0.00% and among their husbands were 0.13%, 0.75%, and 0.00%, respectively, and the proportions of pregnant women had multiple sexual partners were 0.13%, 0.25%, and 0.75%, respectively. Conclusion: The seroprevalence of HIV among pregnant women in Baoshan Prefecture higher than that of the national level, moreover, the awareness of HIV-related knowledge needs to be improved. There is a need to conduct comprehensive interventions to stop HIV in the future.
2014 Vol. 22 (5): 314- [Abstract]（
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Li Li, Chu Guanghua, Jing Xiaopin,et al
Objective: To compare the efficacy, side effects and the influence on the next menstruation of levonorgestrel(LNG) enteric-capsules (Caps) to tablets (Tabs) in emergency contraception. Methods: A randomized multicentre trial was conducted in 30 hospital or family planning institutes around China. A total of 2880 women with regular cycles and history of unprotected intercourse within 72 hours were recruited and randomly assigned to two study groups. Single dose of 1.5 mg LNG enteric-capsule or tablet was taken in Caps group and Tabs group. Follow-up visit was conducted on the 7th day of the expected menstruation to evaluate the contraceptive efficacy and to record side effects and menstruation. Contraceptive efficacy was calculated by Dixon's test method. Results: Five women were lost to follow up. The total valid subjects in Caps and Tabs group were 1908 and 960 respectively. Seven pregnancies occurred in each group, with 0.37% and 0.73% of the pregnancy rate respectively. The relative risk of pregnancy of treatment with1.5mg LNG Cap in comparison with Tab was 0.5 (95%CI: 0.18-1.43). The two drugs prevented about 91% to 95% of the anticipated pregnancy if no measure had been adopted. The efficacy decreased along with the delay of both of the two drugs administration. The pregnancy rate nearly doubled in the women who had unprotected sex after treatment. The incidences of nausea and vomit of the Tab group were significantly higher than those of the Cap group within 24h and 1h of the treatment (P<0.001). Among these women, there were 2 pregnancies (pregnancy rate was 5.9%) occurred in Tab group whereas no pregnancy in Cap group. Other side effects were uncommon and mild. The percentage of subjects who had their next menstruation before or after the expected menstruation 3 days in the two groups was 73.5% and 70% respectively. The menstrual period less than 7 days were 98.3% and 98.7%. Conclusion: 1.5mg of LNG enteric-Caps is effective and safe for emergency contraception. It may decrease the incidence of gastrointestinal effects such as nausea and vomit.
2014 Vol. 22 (5): 319- [Abstract]（
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Zhang Yue, Chu Yujing, Luo Haining, et al
Objective: To explore the influence of atoxiban on the pregnancy outcome in patients with repeated implantation failure (RIF) in freezing embryo transfer (FET). Methods: From November 2012 to January 2013, 240 RIF patients in Reproductive Medical Center of Tianjin Obstetric-Gynecologic Hospital who underwent FET were divided into two groups, in whom 120 cases used atosiban before FET and 120 cases were as the control. Implantation rate and pregnancy outcome were compared between two groups by SPSS18.0 statistical software. Results: The female age, IVF／ICSI constituent ratio, previous failure cycles and infertile factors of patients did not show statistical differences between the treatment group and the control group (P>0.05). The implantation rate of patients in the treatment group increased significantly compared with the control group ［27.0％(75/278) vs. 16.4％(41/250), χ2=4.783，P<0.05］. The clinical pregnancy rate increased significantly in the treatment group compared with the control group ［50.8％(61/120) vs. 29.2％(35/120), χ2=11.736，P<0.05］. The abortion rate, the ectopic pregnancy rate and the multiple pregnancy rate did not show statistical differencse between the treatment group and the control group（P all >0.05）. The living-birth rate increased significantly in the treatment group compared with the control group ［41.7% (50/120) vs. 20.8% (25/120), χ2=12.121，P<0.05］. Conclusion: Atosiban may increase the implantation rate and the pregnancy rate as well as the endometrial receptivity and the pregnancy outcome.
2014 Vol. 22 (5): 325- [Abstract]（
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Cheng Licun, Fan Xiaofang, Lv Yanping, et al
Objective: To investigate the optimal medical regimen for terminating pregnancy in 16-24 weeks of gestation. Methods: This is a multi-center randomized controlled trail with 8 hospitals in Shanghai. A total of 607 women with pregnancy in 16-24w gestation were randomized into three groups. Group I took mifepristone 200mg on day 1 followed by 0.4mg of misoprostol administered vaginally on the third day morning, repeated every 12h (3 times in maximum); Group II took 100mg of mifepristone once a day for two days, the administration of misoprostol was the same as Group I; Group III took mifepristone 200mg on day 1 followed by 0.4mg of misoprostol administered orally on the third day morning and repeated every 6h (4 times in maximum). Results: Successful abortion rates in each group were 97.1% in group I , 96.0% in group II and 92.0% in group III , with statistical significance (χ2=6.05, P=0.048). Totally 577 women expelled their fetus successfully, and the average induction to abortion interval was 13.43±10.18 h, without statistical significance among groups （F=1.01，P=0.36）. The average amount of misoprostol used were 616.33±317.26 g、634.99±307.88 g、797.85±395. 56 g in the three groups respectively (F=16.20, P=0.00). No statistically significant differences were found for 2h and 24h post-abortion hemorrhage volumes among the three groups. Majority of side effects were gastrointestinal discomforts and most were mild cases with no need for intervention. Conclusion: Regimen of group I (mifepristone 200mg po. + misoprostol 400μg pv.) is an optimal for medical abortion in pregnancy with 16-24 weeks of gestation
2014 Vol. 22 (5): 329- [Abstract]（
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