-
-
Wang Haochen,Guo Chao,Li Ning,Zheng Xiaoying
To study the changes of incidence rate of birth defects (BDs) before and after the abolition of mandatory premarital check-ups based on the literature research. Methods: The data of BDs and premarital check-ups were collected from the literatures published before Sept. 9, 2012. The number of BDs cases and that of perinatal infants monitored in many regions in 2002, 2003 and 2005 were extracted. Considering the time of abolition of the mandatory premarital check-ups (Oct, 2003) and its lag effect, we merged the cases of BDs and the number of perinatal infants monitored in 2002 and 2003, respectively, to calculate the incidence rate of BDs and took it as control to be compared with that in 2005. Meta analysis module in STATA 11.0 was employed to take a meta analysis of these incidence rates. Results: The analysis indicates that the incidence rate of BDs in 2005 (a year after the abolition of the mandatory premarital check-ups) is 1.11 times as high as that of the merged incidence rates of BDs in 2002 and 2003 (D+L pooled RR=1.11, 95%CI 1.04-1.18). The difference is statistically significant (P<0.05). Conclusion: After the abolition of the mandatory premarital check-ups, the incidence rate of BDs rose in China. Advocating premarital check-ups and increasing the coverage of premarital check-ups are essential to reduce the occurrence of BDs in China.
2013 Vol. 21 (2): 82-87 [Abstract]（
58
）
HTML
(1 KB)
PDF
(0 KB)
(
4
)
-
Qi Lu,Hao Chanjuan,Xia Hongfei,Ma Xu,Sun Daguang
To investigate the methylation status of genetic imprinted genes H19, PEG10 and IGF2 in the placenta of women with a fetus of neural tube defects (NTDs) at the different gestational weeks and its role in the development of NTDs. Methods: The methylation of genetic imprinted genes H19,PEG10 and IGF2 was detected with the Taqman probe based real-time PCR (Methylight) technology in placenta of 28 active NTDs patients (case group) and 28 healthy controls of different gestational weeks. Results: The methylation of genetic imprinted genes H19, PEG10 and IGF2 was generally detected in the placenta of 28 active NTDs patients and 28 healthy controls. The rate of PEG10 or IGF2 gene hypermethylation in the case group was slightly higher than that of controls. In the case group, the methylation levels of H19 gene started to rise from 21 weeks of gestation, and that of PEG10 or IGF2 gene started to decline from 26 weeks of gestation. The methylation levels of IGF2 gene were significantly higher in the NTDs cases at 31-36 weeks of gestation than those of the control counterparts (P<0.05). Conclusion: The methylation of IGF2 gene may play a role in the development of NTDs..
2013 Vol. 21 (2): 88-93 [Abstract]（
46
）
HTML
(1 KB)
PDF
(0 KB)
(
6
)
-
Li Guoju,Liu Song,Yu Zhenjie,Hou Yunrong,Li Xiangyun
To investigate the current situation of delivery care services and the influencing factors in Chinese women to propose the strategy and policy recommendations to increase the utilization and coverage of the services. Methods: A multi-stage random cluster sampling method was conducted in the country. We randomly sampled three prefecture-level cities in each of three selected provinces of Shandong, Henan and Gansu in accordance with the economic development levels, and then randomly selected 2,021 women who had given birth between July and September in 2009 from the EPI vaccination services and collected the data with a self-designed questionnaire. The data were analyzed with SPSS13.0. Results: The data from 1,945 valid respondents were analyzed. The rate of hospital delivery was 98.61%. Among 1,918 women of hospital delivery, the rate of normal delivery was 65.95% (73.68% in rural women and 58.37% in urban women), the rate of caesarean section was 33.42% (22.31% in rural women and 47.85% in urban women), and the rate of delivery with complications was 0.63% (0.95% in rural women and 0.31% in urban women). The major influencing factors of hospital delivery were nationality and the yearly income of the family. The influencing factors of caesarean section included the place of residence, the number of existing children and the education levels of women. Conclusion: The delivery care services have been improved in the the studied areas. Health education should be strengthened in the perinatal care services in order to increase the rate of hospital delivery and decrease the rate of caesarean section.
2013 Vol. 21 (2): 94-97 [Abstract]（
61
）
HTML
(1 KB)
PDF
(0 KB)
(
4
)
-
Wu Xiaoli,Zhang Jinwen,Hu Chen
To study the current situation of reproductive health in the junior college students of a Nanjing university. Methods: We used a random cluster sampling to recruit the junior college students in Nanjing City and investigated their reproductive health related knowledge, attitude and behaviors, and the related factors. Results: Most of junior college students (90.5%) showed a relatively acceptance to the premarital sex. 16.0% of them had had sexual experiences. The students had some general contraceptive knowledges, but the knowledge about the detailed usage of the methods was relatively limited. 70.7% of those with sexual experience reported the consistent use of condom in each sexual engagement, but the rate of induced abortion was as high as 64.7% in the girl students who had had sex. The related factors to the premarital sex included the high educational levels of the parents, inharmonious parental relation, urban residence, and the divorced families or single-parent family. The proportion of the only child in the group with sexual experience was lower than that in the group without sexual experience. The students got access to the reproductive knowledges from TV/newspaper/books, peer friends, senior family members, internet/media and school courses in decreasing order. Conclusions: The junior college students showed a relatively high tolerance of premarital sex, but their reproductive knowledge was limited and the rate of unexpected pregnancy was high. The family characteristics had some effect on the premarital sex of the students. It is recommended that the universities should strengthen the reproductive health education.
2013 Vol. 21 (2): 98-101 [Abstract]（
68
）
HTML
(1 KB)
PDF
(0 KB)
(
3
)
-
Deng Shunmei,Tang Yunge,Tang Lixin,Ma Chunjie,Wang Qiling,Liu Huang,Jiang Fang,Tang Le
To compare the sperm parameters, sperm function and sperm acrosin activity before freezing and after thawing, and to explore the effect of sperm cryopreservation on sperm function and sperm acrosin activity. Methods: The semen samples were collected from the normal reproductive male volunteers whose semen parameters were above the lower reference limit. The semen parameters, sperm function and sperm acrosin activity before freezing and after thawing were assessed. Results: The vitality (54.96%±6.00%), the ability of spermatozoa to penetrate a column of cervical mucus (1.70±0.47) and the sperm acrosin activity (15.31±8.87 mIU/million sperm) of the frozen-thawed sperm were significantly lower than those of the fresh samples (65.74%±6.62%, 2.65±0.49 and 54.32±36.38 mIU/ million sperm, respectively) (P<0.05). Conclusion: Cryopreservation of sperm can damage the sperm membrane function and the ability of spermatozoa to penetrate a column of cervical mucus in a capillary tube, and decrease the sperm acrosin activity significantly.
2013 Vol. 21 (2): 102-104 [Abstract]（
45
）
HTML
(1 KB)
PDF
(0 KB)
(
3
)
-
Fan Suhong,Xia Lihua
To study the clinical efficacy of two conservative surgical options in the treatment of tubal pregnancy and their effect on the next pregnancy. Methods: A total of 300 patients with tubal pregnancy were divided into two groups, and treated with methotrexate (MTX) + laparoscopy (combination group, n=158) and direct laparoscopic surgery (control group, n=142), respectively. The duration of operation, the intraoperative blood loss, the duration of postoperative β-HCG level's down to normal, the incidence of persistent tubal pregnancy and the next intrauterine pregnancy (IUP) were observed and compared between groups. Results: The average operation time in the combination group was 35.6±12.3 min, shorter than that of the control group (52.8±11.3 min) (P< 0.01); The duration of postoperative β-HCG down to normal in combination group (15.9 ±2.6 days) was shorter than that of control group (21.3±3.7 days) (P<0.01); The intraoperative blood loss in combination group was 45.7±20.1 ml, less than that of the control group (103.0±26.5 ml) (P<0.01); The rate of postoperative persistent tubal pregnancy in combination group was 3.16%, lower than that in control group (10.56%) (P<0.01); The rate of next IUP in the combination group were 68.0%, higher than that in the control group (51.7%) (P<0.01). Conclusions: Combination of MTX and laparoscopy shows a better efficacy in the conservative treatment of tubal pregnancy than direct laparoscopy.
2013 Vol. 21 (2): 105-108 [Abstract]（
65
）
HTML
(1 KB)
PDF
(0 KB)
(
4
)
-
Zhang Xin,Liu Ying
To investigate the clinical efficacy of the fixed levonorgestrel-releasing intrauterine system for the patients with adenomyosis. Methods: A total of 100 patients with adenomyosis were divided into two groups, and inserted with the fixed levonorgestrel-releasing intrauterine system (fixed LNG-IUS group, n=50) and LNG-IUS (control group, n=50), respectively. The pregnancy with IUD in situ, the IUD expulsion rate, the side effects and the non-contraceptive benefits were observed after 3,6,12 months of insertion. Results: In the two groups, no patients experienced a pregnancy with IUD in situ. The expulsion rate of the fixed LNG-IUS group (0%) was significantly lower than that of the control group (10%) (P<0.05). No obvious side effects were found in either group. The VRS scores of algomenorrhea in the fixed LNG-IUS group and control group were 2.45±0.64, 2.53±0.67 before the insertion, respectively, and significantly dropped to 1.53±0.61, 1 .49±0.58 (3 months after insertion), 1.32±0.65, 1.20±0.63 (6 months after insertion) and 0.81±0.62, 0.82±0.61 (12 months after insertion), respectively (P<0.05). There was no significant difference in the VRS scores between the two groups at any corresponding time-points (P>0.05). The scores of pictorial blood assessment chart (PBAC) were significantly lower and the serum hemoglobin levels significantly higher after the insertion of either IUD (P<0.05). Conclusion: The fixed LNG-IUS is a more effective treatment than LNG-IUS for the patients with adenomyosis.
2013 Vol. 21 (2): 109-112 [Abstract]（
49
）
HTML
(1 KB)
PDF
(0 KB)
(
0
)
-
He Fanghua
To study the efficacy of fluorescence in situ hybridization (FISH)) in the prenatal diagnosis of Down syndrome and other chromosomal abnormalities. Methods: The amniotic fluid samples were collected from 589 women at 18-24 weeks of gestation. The chromosome analysis of uncultured interphase amniocytes was done by means of FISH with the probes for chromosome GLP13/21 special sites and CSP 18/X/Y chromosome centromere. The karyotype analysis of the cultured amniocytes served as the standard to evaluate the efficacy of FISH technique. Results: Interphase FISH revealed 589 cases with the normal number of sex chromosomes (196 cases of XX and 290 cases of XY) and 3 cases with abnormal number of sex chromosomes (47, XXY; 47, XXX; 47, XYY), which is consistent with the results of karyotype analysis. FISH also found 6 cases of trisomy 21, 1 case of trisomy 18 and 1 case of trisomy 13, confirmed by karyotype analysis. Karyotype analysis revealed 7 cases of chromosome structural abnormalities. Conclusion: The combination of FISH and karyotype analysis can maximize the detection efficacy in prenatal diagnosis of chromosome abnormalities.
2013 Vol. 21 (2): 113-115 [Abstract]（
56
）
HTML
(1 KB)
PDF
(0 KB)
(
2
)
