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Wang Xia
2012 Vol. 20 (12): 796- [Abstract]（
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Li Yulin, Yin Qiaozhi
In recent years the infertility patients have been increasing, and many investigations showed that infertile women were bothered by a variety of negative emotional distresses. Psychological factors of infertile women affect not only the patient's mental health, but also the treatment outcomes. However, there is no large-scale survey data or systematic analysis available in this field yet. This article aims to provide an overview of the completed investigations with focus on psychological factors of infertile women, and analyze and summarize the mental characteristics and demographic characteristics of the patients, hopefully providing a reference for clinical practice.
2012 Vol. 20 (12): 801- [Abstract]（
54
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Li Xia, Wang Yonghong, Wang Li, Zhao Xiangzhong, Zhou Xianbin, Guo Yuqi, Jiang Guosheng, Yao Chengfang
Objective: To investigate the correlation between Th1/Th2 shift and the volume of uterine bleeding in RU486 medical abortion, and to study the mechanism of "Gongqing decoction" in reducing the volume of uterine bleeding in RU486 medical abortion. Methods: 20 pregnant mice were assigned into RU486 high-dose (1.5 mg/kgod) and low-dose (0.88 mg/kgod) medical abortion groups randomly. The volume of uterine bleeding was measured by the method of alkaline hematin photometry. The percentages of Th1 subset and Th2 subset in the maternofetal interface were determined by flow cytometry. Subsequently, 40 RU486 pregnant mice were assigned into RU486 group (1.5 mg/kgod), Gongqing decoction high-dose (308.16 mg/kgod), mid-dose (154.08 mg/kgod) and low-dose (77.04 mg/kgod) groups randomly. Uterine bleeding volume and Th1/Th2 subsets were assessed by the same methods above. In addition, the mRNA expressions of IFN-γand IL-4 were assessed by RT-PCR. Results: The uterine bleeding volume in RU486 high-dose group was much lower than that in RU486 low-dose group (P<0.05), and the uterine bleeding volume was negatively correlated with the percentage of Th1 subset and the ratio of Th1/Th2 (P<0.05), while positively correlated with the percentage of Th2 subset (P<0.05). Gongqing decoction reduced the uterine bleeding volume efficiently in RU486 medical abortion (P<0.05). The mRNA expression of IFN-γ and the percentage of Th1 cells were up-regulated while the mRNA expression of IL-4 and the percentage of Th2 cells were down-regulated after Gongqing decoction administration (P<0.05). Conclusion: The uterine bleeding volume was closely related to Th1/Th2 paradigm in RU486 medical abortion. Gongqing decoction reduced uterine bleeding volume efficiently by inducing Th1 skew.
2012 Vol. 20 (12): 805- [Abstract]（
52
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Lyu Fang, Pan Yu,Wei Mian, Gu Fangle, Wang Daxin, Zhang Xiaomei*
Objective: To study the effects of Chitosan on endometrial carcinoma cell lines in vitro. Methods: Chitosan at different concentrations were added to the culture medium of endometrial cancer cell line Ishikawa, as the experiment groups, while 20% FBS and 5μg/ml adriamycin added as positive control, and there was another blank control group with nothing added. Each group was treated for 48 hours. Cell proliferation was determined by MTT assays and BrdU incorporation ELISA. The apoptosis rate and cell cycle in Ishikawa cells were detected by flow cytometry. Results: When treated with 10μg/ml chitosan for 48h, the growth of Ishikawa cells was not significantly different from that of blank control group (P>0.05).Treatment with ≤10μg/ml chitosan for 48 hours did not significantly alter Ishikawa cell DNA synthesis when compared with the control (P>0.05). Chitosan at the concentration of ≤100μg/ml showed no significant cytotoxicity. Flow cytometry showed that 10μg/ml chitosan had no significant impact on the S and G1 and G2 Phases of cell cycle compared with blank control group (P>0.05). Conclusion: Chitosan at concentration of less than 10μg/ml had no effects on Ishikawa cell proliferation and cycling. It is indicated that chitosan can be used as drug carrier material in intrauterine device (IUD).
2012 Vol. 20 (12): 809- [Abstract]（
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Lin Ting, Zheng Xiaoying
Objective: To explore the status and influencing factors of sexual behavior among unmarried floating youths, and provide a basis for reproductive health education among floating youths. Methods: This study used the first nationally representative data on sexual and reproductive health of Chinese unmarried youth. According to the time criterion, 3,032 unmarried floating youth were selected in this study. Results: 36.7% of the studied floating youths had had sexual experience, higher than the proportion among non-floating youths group (P<0.05); The rate of multiple sexual partners was 21.5% among floating youth in the past 12 months; The floating youths with higher age, higher income level, drinking alcohol, living in western part of China, living in the city/town, visiting pornographic website or reading porno occasionally/frequently were more likely to have sexual behavior than their counterparts. Conclusion: Higher incidence of the sexual behavior was found among the floating youth. Multiple factors affect the floating youths having engaged in sexual behavior.
2012 Vol. 20 (12): 813- [Abstract]（
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Zhang Ou, Zhang Yan-er, Chai Liping, Miao Mouhua, Liang Hong
Objective: To explore the prevalence of sex-related behaviors and the use of contraceptive methods among unmarried business staffs aged 20-35. Methods: A total of 1,775 office workers from a business building were interviewed by trained investigators with structured questionnaire. This study was based on 1,192 unmarried ones out of the 1,775 staffs interviewed. Results: The prevalence of sex intercourse was 24% and 12% for unmarried men and women, respectively. Among the respondents who reported to have had intercourse, 54% reported to use contraceptive methods every time of intercourse. The most commonly used method was condom, with a rate of 80%. Logistic regression results indicated that older age, registered residence out of shanghai, alcohol drinking, lower score of WHOQOL-BREF and having a partner were the risk factors of premarital sex-related behavior. Conclusion: Family planning service providers should provide knowledge and counselling on the sex-related behavior and contraception targeting the need of unmarried young business people.
2012 Vol. 20 (12): 817- [Abstract]（
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Duan Xiuling, Liu Yi, Yan Yan, Jiang Nongying
Objective: To investigate the current situation of sex behavior and contraceptive use of adolescent girls who seek an abortion, thus to explore the influencing factors of unwanted pregnancy and induced abortion. Methods: A cross-sectional survey was conducted on 525 teenage girls who sought an abortion in this hospital from May 2009 to April 2010 with a self-administered questionnaire. All data were input with Epidata3.1 and analyzed with SPSS16.0. Results: As to the current unwanted pregnancy, 67.6% were due to unprotected intercourse, and 25.2% were resulted from contraceptive failure. The main reason for non-use of contraception was "occasional sex behavior couldn't result in pregnancy". The failed contraceptive methods, in sequence, were withdrawal, condom, rhythm and emergency contraception. In the last 6 months, 25.2% never used any contraceptive methods, and the rate of consistent contraceptive use was only 4.2%. The prevalence of premarital cohabitation was higher in those from countryside than that in those not from countryside. Stepwise regression logistic analysis showed that age and income were the significant influencing factors of the repeated induced abortion (P=0.04 and P=0.00, respectively). Conclusions: Premarital cohabitation, low education level, lack of knowledge or unreliable knowledge, non-consistent use of contraception and the choice of the contraceptive methods of low efficacy are related to the increased risk of unintended pregnancy and induced abortion. It is urgent to take measures to educate the countryside girls/women and migrants with the sex and contraceptive knowledge, to encourage the partner's participation in family planning, and to increase the access to use of modern contraceptive methods and the post-abortion services.
2012 Vol. 20 (12): 822- [Abstract]（
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The task group of contraceptive management, Li Chunping, Liu Yue
Objective: To explore the intergenerational differences of contraceptive awareness and practice among the floating population in Jiangsu Province. Methods: An anonymous questionnaire was used to survey the floating population in Jiangsu Province. A total of 7,758 floating people in 13 cities were surveyed, of which 3,584 were new generation. Results: The contraceptive awareness in new generation was a little better than in old generation. 12.93% in new generation and 11.43% in old generation did not know how to use emergency contraceptives. The family planning service providers were the main source of contraceptive knowledge. People of old generation were more likely to choose contraceptive pills, injectable contraceptive, external forms and contraceptive implant, while the condom use was higher in the new generation. Conclusion: The contraceptive awareness and practice between new and old generations were different. Different demands and preferences between different people should be taken into consideration when dispensing contraceptives. Services for the floating population should be provided in a well-targeted manner.
2012 Vol. 20 (12): 825- [Abstract]（
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Hou Qunjie, Zhai Weihua, Yang Rui, Li Wenzhen, Dong Xiaoxin, Xu Huan, Tong Yeqing
Objective: To make a comprehensive analysis on the effect of the project of "contraceptive kit available in maternity ward" carried out in Wuhan. Methods: The potential respondents were selected by cluster random sampling method and interviewed by telephone with a questionnaire. SPSS16.0 and Excel2003 were used to analyze the data. Results: The response rate of telephone interview was 10.03% in this study, and 505 of 508 interviewed respondents returned the valid response, which calculated the effective rate of 99.4%. The utilization rate of contraceptive kit among the respondents was 63.6%, and condoms were the most commonly used method. 83.6% of the respondents reported the use of contraceptive methods at their first postpartum sex. The satisfaction rate for the quantity, quality, diversity of the contraceptive kit, leaflets, and the unique distribution channel was 63.1%, 51.6%, 47.7%, 41.6% and 93.9%, respectively. Conclusion: Making contraceptive methods available in maternity ward is an effective way for the distribution. The utilization rate of free contraceptive kit is relatively high, but there is still greater room for improvement.
2012 Vol. 20 (12): 829- [Abstract]（
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Hu Rong, Song Xueru, Yue Tianfu, Bai Xiaohong, Zhao Xiaohui, Lyu Rui, Zhang Huijuan, Wang Yanxia, Jiang Changxin
Objective: To investigate the effect of dehydroepiandrosterone (DHEA) supplementation on in vitro fertilization and embryo transfer (IVF-ET) outcomes among the patients with diminished ovarian reserve (DOR). Methods: A self-control study was conducted on 47 DOR patients treated with IVF/ICSI from Jan 2007 to Aug 2012 in our center. The parameters of ovarian reserve and IVF outcomes between the cycles before and after DHEA treatment were compared, including basal hormone levels, antral follicle count (AFC), the number of follicles, the number of oocytes retrieved, fertilization rate, cleavage rate, implantation rate, clinical pregnancy rate, the cycle cancellation rate and abortion rate. Results: The ovarian stimulation protocols were similar between the cycles with and without DHEA treatment. A significant increase was noted in AFC, number of follicles and retrieved oocytes after DHEA treatment (P<0.05), and cleavage rate, implantation rate and clinical pregnancy rate were improved significantly as well (P<0.05). There was no significant difference in fertilization rate, abortion rate or cycle cancellation rate (P>0.05), but there was a trend towards a reduced cycle cancellation rate after DHEA treatment. Conclusion: DHEA treatment has a beneficial effect on the DOR patients, and could enhance ovarian response and improve the clinical outcome.
2012 Vol. 20 (12): 832- [Abstract]（
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Meng Yushi, Zhou Honglin,Yang Jie, Chen Jinbao
Objective: To examine the value of age, basal levels of follicle-stimulating hormone (bFSH), estradiol (bE2) and antral follicle count (AFC) in predicting ovarian response in in vitro fertilization and embryo transfer (IVF-ET) cycles. Methods: A total of 736 patients who had IVF-ET treatment were analysed retrospectively. The patients were divided into different groups according to the age (years <35, 35~, 38~), levels of bFSH (<10U/L, ≥10 U/L), bE2 (<292.8pmol/L, ≥292.8pmol/L) and AFC (<5, ≥5). The relationship between these parameters and ovarian response was examined. Results: The number of oocyte retrieved was significantly correlated with age (P<0.001), bFSH (P<0.001), AFC (P<0.001) and bE2 (P<0.05). ROC analysis indicated that AFC was the most sensitive parameter, followed by age. The sensitivity in prediction was relatively low for the single parameter, but highly increased when used in combination. Conclusion: Age, bFSH, bE2 and AFC had their respective value in predicting ovary response, and AFC was the most important one that could predict the poor ovary response when combined with one of the other three parameters.
2012 Vol. 20 (12): 836- [Abstract]（
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Yi Yanping, Zhang Qingde, Chen Liang, Lin Peixuan, Li Yawen, Diao Weijian, Yuan Yuzhi, Xin Huijin
Objective: To study the impact of psychological intervention on propofol anesthetic dose, vital sign profiles and anesthetic complications in the birth control operations. Methods: The patients requesting an induced abortion or tubal ligation were randomly divided into intervention group (R1 group, L1 group) and control group (R2 group, L2 group). Those in intervention group (R1, L1) were given psychological interventions in the whole process of treatment, while those in control group (R2, L2) were treated with the standard procedures. SAS and SDS scores were determined at the first visit and before surgery for all patients. The first propofol dose, total propofol dose, and basal, preoperative and intraoperative MBP and heart rate (HR), and any anesthetic complications were recorded and compared. Results: Preoperative SAS and SDS scores, preoperative MBP and HR, and the first dose of propofol were all significantly lower in intervention group than in control group (P<0.05). The incidence of intraoperative/postoperative anesthetic complications in control group was significantly higher than that in the intervention group(P<0.05). Conclusion: The psychological intervention could help to relieve the level of anxiety, maintain hemodynamic stability, and reduce the first propofol dose and the incidence of complications.
2012 Vol. 20 (12): 840- [Abstract]（
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