To investigate the predictive efficacy of D-dimer/platelet ratio(DPR) of patients with pernicious placenta previa(PPP) for their postpartum hemorrhage. Methods: The clinical data of 102 patients with PPP admitted to the hospital from January 2021 to January 2023 were collected. The D-dimer level and the platelet counts of the patients were detected, and the DPR was calculated. According to whether the patients with PPP complicated with postpartum hemorrhage(postpartum hemorrhage ≥500 ml after vaginal delivery, or postpartum hemorrhage ≥1000 ml within 24 hours after cesarean section), these patients were divided into group A(27 patients with postpartum hemorrhage) and group B(75 patients without postpartum hemorrhage). The predictive efficacy of DPR of the patients with PPP for their postpartum hemorrhage was evaluated by receiver operator characteristic(ROC) curve. The influencing factors of the postpartum hemorrhage of the patients with PPP were explored by binary logistic stepwise regression analysis. Results: The D-dimer level(0.94±0.41 mg/L), the DPR(0.67±0.24) of the patients in group A were significantly higher than those(0.36±0.25 mg/L and 0.29±0.12) of the patients in group B. The platelet count(243.96±32.51×109/L) of the patients in group A was significantly lower than that(301.02±40.39×109/L) of the patients in group B(all P<0.05). The optimal cut-off value and the area under the curve of the DPR of the patients with PPP for predicting their postpartum hemorrhage were 0.46 and 0.914. Logistic stepwise regression analysis showed that the age ≥35 years old(OR=1.260), the penetrate placenta percreta(OR=3.284), the DPR≥0.56(OR=5.094) of the patients with PPP were all the risk factors of their postpartum hemorrhage(all P<0.05). Conclusion: The DPR of the patients with PPP and postpartum hemorrhage is highly expressed, and the DPR of the patients with PPP has certain clinical efficacy for predicting their postpartum hemorrhage postpartum.