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| Effect of chinese patent drug Guilingji combined with levocarnitine for treating male patients with infertility because of kidneyyang deficiency and its influence on the sperm quality and sex hormones levels |
1.Chenghua District Women and Children's Hospital, The Second Hospital of West China, Sichuan University(Chengdu Chenghua District Maternal and Child Health Care Hospital), Chengdu, Sichuan Province, 610000;
2.Sichuan Hospital of Urology, Chengdu; 3.Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu |
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Abstract To investigate the effect of chinese patent drug Guilingji combined with levocarnitine for treating male patients with infertility because of kidney-yang deficiency. Methods: 205 male patients with oligospermia and asthenospermia were selected and were randomly divided into group A(102 cases) and group B(103 cases) from January 2022 to December 2023. The patients in both groups were given basic symptomatic treatment and asthenospermia, and the patients in group B was given Guilingji additionally. The patients in both groups were treated for 12 weeks continually. The therapeutic effect, the TCM syndrome score, the sperm quality, the levels of sex hormones, such as luteinizing hormone(LH), testosterone(T) and follicle stimulating hormone(FSH), and the levels of oxidative stress, such as seminal plasma malondialdehyde(MDA), reactive oxygen species(ROS) and superoxide dismutase(SOD) of the patients in the two groups were counted. Results: In group A, there were 99 patients were included, with 1 case withdrawing by himself and 2 cases without complete the study records. In group B, there were 101 patients were included, with 1 case lost to follow-up and 1 case withdrew due to personal factors. The scores of primary symptom(8.51±2.53 points), the second symptom and tongue symptom(3.34±1.02 points) and the total TCM syndrome(11.85±3.45 points) of the patients in group B after treatment were significantly lower than those(12.15±3.20 points, 5.02±1.24 points and 17.17±3.83 points) of the patients in group A. The total effective rate(82.2%) of the patients in group B after treatment was significantly higher than that(67.7%) of the patients in group A. The sperm concentration(30.15±5.45×106/ml), the percentages of grade A(27.26±4.33%) and grade A +B(54.46±6.58%) of sperm forward movement of the patients in group B were significantly higher than those(22.04±4.62 ×106/ml,(24.36±4.18% and 48.52±5.16%) of the patients in group A. The levels of the serum luteinizing hormone(3.87±1.01 U/L) and follicle-stimulating hormone(5.24±1.78 U/L), and the levels of seminal plasma ROS(425.26±86.18U/ml) and MDA(6.25±1.73nmol/L) of the patients in group B were significantly lower than those(4.21±1.23 U/L, 6.32±2.26U/L, 463.73±82.67U/ml and 7.12±1.64nmol/L) of the patients in group A. The levels of serum testosterone(15.54±1.96nmol/L) and seminal plasma SOD(102.54±18.02U/ml) of the patients in group B were significantly higher than those(13.68±2.02nmol/L and 95.10±15.25U/ml) of the patients in group A(all P<0.05). Conclusion: Guilingji combined with levocarnitine for treating the male infertility patients can significantly alleviate their clinical symptoms and improve the therapeutic effect, which may be related to the improvement of the sperm quality, to the regulation of sex hormones expressions and to the reduction of oxidative stress injury of the patients.
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