To understand the postpartum depression status of advanced multiparas(≥35 years old), and to analyze the influencing factors of the postpartum depression. Methods:  Convenience sampling method was used to select the advanced multiparas who had delivered hospitalized in Hangzhou obstetrics and gynecology hospital from June to December 2023 as the research objects. The demographic information and the delivery data of these multiparas were collected. The postpartum depression status and the social support level of these multiparas were investigated by Edinburgh postpartum depression scale(EPDS) and social support rating scale(SSRS). Logistic regression was used to analyze the related influencing factors of the postpartum depression of these multiparas. Results: There were 88(31.0%) cases with postpartum depression(EPDS score ≥13 points) in 284 advanced multiparas. Multivariate logistic regression analysis showed that the family per capita income <4000 Yuan(OR=2.61, 95%CI 1.27-5.36), the unplanned pregnancy(OR=3.21, 95%CI 1.43-7.22), the low birth weight of the newborns(OR=5.11,95%CI 2.01-12.97), the prenatal depression(OR=4.03, 95%CI 1.76-9.19), the sleep disorders(OR=2.07, 95%CI 1.15-3.71) and the artificial feeding(OR=3.06, 95%CI 1.37-6.83) of the advanced multiparas were the independent risk factors of their postpartum depression occurrence(P<0.05). The social support level(OR=0.26, 95%CI 0.11-0.66) of the advanced multiparas was the protective factor of their postpartum depression occurrence(P<0.05). Conclusion: The incidence of postpartum depression of the advanced multiparas is high, which is related to their low family economic status, their unwanted pregnancy, their low neonatal weight, their artificial feeding, their prenatal depression, their sleep disorder and their insufficient social support, and so on.