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| Value of TORCH combined with serum human chorionic gonadotropin, alpha-fetoprotein and free estriol levels of pregnant women with abnormal ultrasound soft index for diagnosing their fetus situation |
| Urumqi Maternal and Child Health Care Hospital，Urumqi, Xinjiang Uygur Autonomous Region, 830000 |
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Abstract To explore the value of TORCH combined with the serum human chorionic gonadotropin (β-hCG), alpha-fetoprotein (AFP) and free estriol (uE3) levels of pregnant women with abnormal ultrasound soft index for diagnosing their fetus situation. Methods: A total of 324 pregnant women with abnormal fetal ultrasound soft indexes, including 300 with single abnormal ultrasound soft indexes and 24 with multiple abnormal ultrasound soft indexes, who underwent prenatal examination in hospital from July 2021 to December 2023 were selected in study group, and in addition, 300 healthy women who underwent prenatal examination in hospital during the same period were selected in control group. TORCH serological test and the detections of the levels of serum AFP, free-βhCG and uE3 were all performed in the pregnant women in the two groups. The results of TORCH and the serum β-hCG, AFP and uE3 levels of the women were compared between the two groups. The results of TORCH, and the serum β-hCG, AFP and uE3 levels were compared between among the women with different abnormal ultrasound soft indexes. Receiver operator characteristic (ROC) curve analysis was used to analyze the value of TORCH combined with the serum β-hCG, AFP and uE3 levels of the women with abnormal ultrasound soft indicators for diagnosing the fetus situation. Results: The positive rate of serum TORCH detection, and the β-hCG, AFP and uE3 levels of the women in the study group were significantly higher than those of the women in the control group, and the serum uE3 level of the women in the study group was significantly lower (all P<0.05). The positive rate of serum TORCH detection, and the β-hCG, AFP and uE3 levels of the women with multiple abnormal ultrasound soft indexes were significantly higher than those of the women with single abnormal ultrasound soft index, the serum uE3 level of the women multiple abnormal soft indexes was significantly lower (all P<0.05). ROC curve results showed that the area under the curve (AUC) of the combined detections of serum TORCH, β-hCG, AFP and uE3 of the women with abnormal ultrasound soft index for diagnosing their fetus situation was 0.927, which was significantly higher than that of the serum TORCH detection, the β-hCG level, the AFP level or the uE3 level alone. The sensitivity and the specificity of the combined detections of serum TORCH, and the β-hCG, AFP and uE3 levels of the pregnant women with abnormal ultrasound soft index for diagnosing their fetus situation were 90.00% and 92.59%, and which were higher. Conclusion: The serum TORCH detection combined with theβ-hCG, AFP and uE3 levels of the pregnant women with abnormal ultrasound soft index can help to improve the prenatal diagnosis rate of their fetuses abnormity, and which can provide an accurate and effective diagnositic method in clinic.
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