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| Application value of thin layer liquid cytology test combined with human papillomavirus detection for screening the cervical cancer and the correlation between the cervical cancer and vaginal infection |
1. Yinzhou District Baizhang Street Community Health Service Center，Ningbo, Zhejiang Province, 315040；
2. Zhoushan Hospital, Zhoushan, Zhejiang Province |
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Abstract To investigate the application value of thin layer liquid cytology test (TCT) combined with human papillomavirus (HPV) detection for screening the cervical cancer, and to study the correlation between the cervical cancer of women and their vaginal infection. Methods: The clinical data of 483 women who underwent cervical lesion screening from July 2022 to July2023 were collected in this study, and these women were given TCT and HPV detection. According to the pathological diagnosis results, the women were divided into 467 women without cervical cancer in control group and 16 women with cervical cancer in observation group. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of TCT and HPV detection for screening the cervical cancer. The incidence of vaginal infection and the vaginal microecology of the women were compared between the two groups. Results: Based on the pathological results, the accuracy of TCT, HPV and the combined detection of TCT and HPV of the patients for diagnosing their cervical cancer were 92.3%, 92.6% and 98.1%, respectively. ROC analysis showed that the area under the curve of the combined TCT and HPV detection for diagnosing the cervical cancer was 0.953, which was significantly higher than that (0.777) of TCT and that (0.808) of HPV detection. The specificity and the sensitivity of the combined TCT and HPV detection for diagnosing the cervical cancer were 96.8% and 93.8%, and which were significantly higher (P<0.05). The vaginal infection rate (93.8%), and the positive rates of hydrogen peroxide (56.3%) and lactobacillus (50.0%) of the women in the observation group were significantly higher than those (29.1%, 31.1% and 21.0%) of the women in the control group. The positive rates of sialidase (6.3%) and leukocyte esterase (43.8%) of the women in the observation group were significantly lower than those (28.9% and 75.4%) of the women in the control group (all P<0.05). Conclusion: The combined TCT and HPV detection for screening the cervical cancer has higher application value. The vaginal infection rate of the women with cervical cancer increases, and the vaginal microecology of the women with cervical cancer has changed, which needs more clinical attention.
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