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| Differential diagnostic value of the ultrasound combined with the values of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio, and the carbohydrate antigen 125 level of patients for their endometrial cancer |
| People's Hospital of Rugao, Jiangsu Province, 226500 |
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Abstract To study the differential diagnostic value of the ultrasound combined with the values of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR), and the level of carbohydrate antigen 125 (CA125) of patients for their endometrial cancer. Methods: 92 patients with endometrial cancer admitted to hospital from January 2020 to October 2022 were selected in study group, and 82 patients with benign endometrial lesions were selected in control group during the same period. The values of blood flow pulsatility index (PI), resistance index (RI) and peak systolic velocity (PSV) of the patients in the two groups were detected by ultrasound. The NLR and PLR values and the serum level of CA125 of the patients in the two groups were detected. Receiver operating characteristic (ROC) curve was used to analyze the values of above indexes of the patients for differential diagnosing their endometrial cancer. Results: The PSV value of the ultrasound blood flow parameters of the patients in the study group was significantly higher than that of the patients in the control group, but the values of PI and RI of the patients in the study group were significantly lower than those of the patients in the control group. The values of PSV of the ultrasound blood flow parameters of the patients with stage III-IV of endometrial cancer in the study group were significantly higher than that of the patients with stage I-II of endometrial cancer, and the PI and RI values of the patients with stage III-IV of endometrial cancer were significantly lower than those of the patients with stage I-II of endometrial cancer. The levels of serum CA125, NLR and PLR of the patients in the study group were significantly higher than those of the patients in the control group, and which of the patients with stage III-IV of endometrial cancer in the study group were significantly higher than that of the patients with stage I-II of endometrial cancer (all P<0.05). ROC curve analysis showed that the area under the curve of the ultrasound blood flow parameters values, the CA125 level, the NLR level, the PLR level and the combined ultrasound blood flow parameters values and the levels of the CA125, NLR and PLR of the patients for differential diagnosing their endometrial cancer were 0.813, 0.892, 0.717, 0.632, and 0.952, respectively, and the combined ultrasound blood flow parameters values and the levels of the CA125, NLR and PLR of the patients for diagnosing their endometrial cancer had the best diagnostic efficiency, with a sensitivity of 98.2%. Conclusion: The ultrasound blood flow parameters values, and the CA125 level, the NLR level and the PLR level of the patients with endometrial cancer are abnormal. The combined ultrasound blood flow parameters values and the levels of the CA125, NLR and PLR of the patients for diagnosing their endometrial cancer has higher differential diagnostic efficiency, which has better clinical guiding value.
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