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| Effect of Longdan xiegan decoction combined with western medicine for treating cervicitis and its influence on the inflammatory level of the cervical secretion |
| 1. Longyou County Traditional Chinese Medicine Hospital, Quzhou, Zhejiang Province, 324400; 2. Longyou County Traditional Chinese Medicine Hospital, Quzhou |
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Abstract To explore the efficacy of Longdan xiegan decoction combined with azithromycin for treating cervicitis of patients, and to study its influence on the vaginal microecology and cervical inflammatory response of the patients. Methods: A total of 80 patients with cervicitis treated in hospital were selected and were randomly divided into study group and control group (40 cases in each group) according to the numerical table method from January 2019 to October 2023. The patients in the two groups were treated with azithromycin, and the patients in the study group were treated with Longdan xiegan decoction additionally. The efficacy, the incidence of adverse reactions, the score of TCM syndrome, the values of immune function index, the inflammatory factors of cervical secretion and the relative abundance change of vaginal flora of the patients in the two groups after 1 month of treatment were observed. Results: After treatment, the total effective rate (90.0%) of the patients in the study group was significantly higher than that (70.0%) of the patients in the control group. Four TCM syndrome scores of increased leucorrhea, leucorrhea thickness, lower abdominal pain and vulva pruritus of the patients in the study group were significantly lower than those of the patients in the control group. The levels of CD3+ (54.47±1.85), CD4+ (27.84±1.79) and the relative abundance of lactobacillus (45.67±0.97) of the patients in the study group were significantly higher than those (46.19±2.49, 23.12±1.37 and 40.95±1.72) of the patients in the control group. The gardnerella relative abundance (5.10±0.07), and the levels of TNF-α (4.85±0.65 ng/L) and CRP (6.70±0.97 mg/L) of the patients in the study group were significantly lower than those (5.68±0.05, 6.91±0.61 ng/L and 10.68±1.07 mg/L) of the patients in the control group (all P<0.05). There was no significant difference in the incidence of the adverse reactions (15.0% vs.17.5%) of the patients between the two groups (P>0.05). Conclusion: Longdan xiegan decoction combined with azithromycin for treating cervicitis of the patients can improve the curative effect, can reduce inflammation response and control clinical symptoms, can improve the vaginal microenvironment and enhance the immunity of the patients, and without increasing the risk of adverse reactions, which is an effective and safe clinical treatment for the cervicitis of the patients.
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