To analyze the current status of the caregiver burden of patients with gynecological malignant tumor, and to study its influencing factors. Methods: Convenience sampling method was used to select the caregivers of the patients with gynecological malignant tumor who visited to hospital from March 2022 to January 2024 in this questionnaire survey. The total score of caregivers burden inventory (CBI) used to evaluate the level of the care burden of the caregivers of the patients was 96 points, and these caregivers were divided into group A (the caregivers with CBI score of 0-32 points) and group B (the caregivers with CBI score of 3396 points). The univariate and multiple regression analysis were used to identify the possible influencing factors of CBI of the caregivers. Results: A total of 297 survey questionnaires were distributed and 290 valid questionnaires were returned, with an effective rate of 97.6%. The CBI score of 290 caregivers of the patients with gynecological cancer was 60.36±5.55 points, including 110 (37.9%) cases in group A and 180 (62.1%) cases in group B. The univariate and logistic regression analysis showed that the advanced age, the low education level, the low monthly income, the residence in rural, and the longer daily care time of the caregivers, and the longer duration of gynecological cancer and the more numbers of annual hospitalization of the patients were the factors affecting the CBI score of the caregivers (P<0.05). Conclusion: The CBI score of the caregivers of the patients with gynecological malignant tumor is higher, with the relatively heavy of care burden. The advanced age, the low education level, the low monthly income, the residence in rural and the longer daily care time of the caregivers, and the longer duration of gynecological malignant tumor and the greater number of annual hospitalization of the caregivers of the patients with gynecological malignant tumor are the independent factors affecting the CBI score of the caregivers. Improving the social and the family support, constructing a health management model based on the hospital-community-family triple linkage for the caregivers can help to alleviate their care burden, which is of great significance for the treatment and the rehabilitation of the patients with gynecological malignant tumor.