To explore the correlation between the blood glucose level and the weight gain of pregnant women during pregnancy and their pregnancy outcomes. Methods: The clinical data of 100 pregnant women who had given birth in hospital from January 2022 to December 2022 were selected in this study. These women were divided into group A1 (women with adverse pregnancy outcomes) and group A2 (women with normal pregnancy outcomes) according to the occurrence of adverse pregnancy outcomes. According to the fasting blood glucose (FPG) level of the women, these women divided into group B1 (women with FPG level ≥5.1mmol/L) and group B2 (women with FPG level <5.1mmol/L). According to standard of the guidelines of the diagnosis and treatment of hyperglycemia in pregnancy (2022 edition), these women divided into group C1 (women with insufficient weight gain), group C2 (women with normal weight gain during regency) and group C3 (women with excessive weight gain during regency). The influencing factors of the adverse pregnancy of the women and the incidence of the adverse pregnancy outcomes of the pregnant women with different indicators were analyzed. Results: The incidence of the adverse pregnancy outcomes of these women was 47.0%. The FPG level (6.56±1.22 mmol/L) and the weight gain during pregnancy (12.52±3.42 kg) of the women in group A1 were significantly higher than those (5.44±1.35 mmol/L and 10.55±2.89 kg) of the women in group A2. The abnormal increase of the FPG level and the weight gain during pregnancy of the women were the risk factors of their adverse pregnancy outcomes (all P<0.05). The incidences of the macrosomia, the neonatal asphyxia, the premature delivery and the premature rupture of membranes of the women in group B1 were significantly higher than those of the women in group B2. The incidences of macrosomia, the cesarean section and the neonatal asphyxia of the women in group C3 were significantly higher than those of the women in group C1 and those of the women in group C2, and the low birth weight incidence of the women in group C1 was significantly higher than that of the women in group C2 and that of the women in group C3 (all P<0.05). Conclusion: The FPG level and the increase of the weight gain during pregnancy of the pregnant women will affect their pregnancy outcomes directly. The increase of the FPG level and the excessive weight gain during pregnancy of the pregnant women will increase the risk of their adverse pregnancy outcomes, so the FPG level and the weight gain during pregnancy control of the pregnant women should be paid attention to.