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| Clinicopathological observation of 8 patients with ovarian granulosa cell tumor and the literature review |
| The Fifth People's Hospital Affiliated to Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611100 |
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Abstract To investigate the clinicopathological features, diagnosis, differential diagnosis and prognosis of the ovarian granulosa cell tumor of patients. Methods: 8 patients with ovarian granulosa cell tumor diagnosed in hospital from 2013 to 2021 were collected. The clinicopathological characteristics and immunohistochemical phenotype of these patients were analyzed. And the literatures about ovarian granulosa cell tumor were reviewed. Results: The mean age of the patients with ovarian granulosa cell tumor was 54 years old. All the patients had undergone surgical treatment and had survived except 1 patient who died because of the recurrence of the ovarian granulosa cell tumor in the 8th year after surgery. The mean size of the tumors of the patients was 10.38 cm, and the tumors had showed the cystic, multilocular cystic or solid. Microscopically, the tumors cells were arranged in a diffuse and solid pattern, and some tumors cells had showed the pseudopapillary, island, or nested pattern, and were separated by the fibrous stroma with rich cells. Immunohistochemical analysis showed that the tumor cells were positive for α-Inhibin, Vimentin and CD99, but were negative for EMA and CK7. Conclusion: Granulosa cell tumor of the ovary is a low-grade tumor with various manifestations under the microscope. Immunohistochemical staining and gene detection can assist in the diagnosis of the granulosa cell tumor of the ovary. Surgical treatment is the main method for the tumor, which may have the long-term recurrence, so the regular follow-up of the patients is required.
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