To investigate the changes of coagulation function and hemodynamics, and the maternal-neonatal outcomes of pregnant women with intrahepatic cholestasis of pregnancy (ICP) complicated with hypertensive disorder complicating pregnancy (HDP). Methods: The clinical data of 60 pregnant women with ICP in group A, 60 pregnant women with ICP complicated with HDP in group B and 60 healthy pregnant women in group C from June 2019 to June 2023 were collected retrospectively. The changes of coagulation function and hemodynamics of the women in the three groups were analyzed. The maternal-neonatal outcomes of the women in the three groups were counted. Results: The serum prothrombin time (12.19±1.39s, 11.18±1.05s and 10.62±1.22s), the thrombin time (16.15±0.72s, 15.24±0.66s and 13.12±0.62s), and the activated partial thromboplastin time (26.37±4.18s, 25.06±3.27s and 23.41±3.05s) of the women in group C, in group A and in group B had decreased gradually. The fibrinogen level (4.15±0.45 g/L, 4.58±0.52 g/L, 4.98±0.61 g/L), the values of umbilical artery resistance index, pulsatility index and the ratio of the peak systolic velocity to the end diastolic velocity of the women in group C, in group A and in group B had increased gradually. The delivery gestational weeks (39.3±1.6 weeks, 38.4±1.7 weeks and 38.0±1.4 weeks) of the women in group C, in group A and in group B had decreased gradually. The incidences of cesarean section and amniotic fluid contamination above grade II of the women in group C, in group A and in group B had increased gradually. The incidences of the preterm birth (1.7%, 15.0% and 18.3%), the low birth weight (0, 6.7% and 10.0%) and the neonatal asphyxia (0, 10.0% and 13.3%) of the women in group C, in group A and in group B had increased gradually (all P＜0.05). There was no significant difference in the incidence of intrauterine fetal death of the women among the three groups (P＞0.05). Conclusion: The coagulation function and hemodynamic indicators of the pregnant women with ICP complicated with HDP have changed significantly, which can influence the maternal-neonatal outcomes. The close monitoring the relevant indicators is of great significance for improving the maternal-neonatal outcomes.