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| Diagnostic value of 3.0T high-resolution magnetic resonance imaging combined with the levels of serum matrix metalloproteinase 9 and pre gradient protein 2 for the FIGO staging of cervical cancer of patients |
| 1. Jinting Hospital of Sihong, Suqian, Jiangsu Province, 223900; 2. Suqian Third Hospital, Jiangsu Province; 3. Jinting Provincial People's Hospital, Jiangsu Province |
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Abstract To explore the diagnostic value of 3.0T high-resolution magnetic resonance imaging (HR-MRI) combined with the levels of serum matrix metalloproteinase 9 (MMP 9) and pre gradient protein 2 (AGR2) for the FIGO staging of cervical cancer of patients. Methods: The clinical data of 122 patients with cervical cancer who were diagnosed and treated in hospital from March 2016 to October 2022 were selected in this study. According to the FIGO staging system of cervical cancer, 64 patients with cervical cancerⅠ-Ⅱ stage were in group A and 58 patients with cervical cancer Ⅲ-Ⅳ stage were in group B. The patients in the two groups were examined by 3.0T HR-MRI, and the levels of serum MMP9 and AGR2 of the patients in the two groups were measured by enzyme linked immunosorbent assay (ELISA). Based on the postoperative pathological results, the consistency of between 3.0T HR MRI alone and 3.0T HR MRI combined with the serum MMP9 and AGR2 levels for diagnosing the FIGO staging of cervical cancer of patients was analyzed by consistency Kappa test. Receiver operating characteristic (ROC) curve was drawn to analyze the diagnostic efficacy of the serum MMP9 and AGR2 levels and the parameters of 3.0T HR-MRI of the patients with cervical cancer for their FIGO stage. Results: The levels of serum MMP9 and AGR2 of the patients in group B were significantly higher than those of the patients in group A (P＜0.05).The area under curve (AUC) of the serum MMP9 level and the AGR2 level of the patients for diagnosing their cervical cancer stage Ⅰ-Ⅱ or stage Ⅲ-Ⅳ were 0.789 (95%CI 0.708-0.869) and 0.836 (95%CI 0.765-0.906), the specificity of which were 76.6% and 73.4%, the sensitivity of which were 72.4% and 81.3%, and the cut-off values of which were 178.83 ng/ml and 13.18 ng/ml. The consistency of 3.0T HR-MRI with the postoperative pathologic results was high, with the Kappa value of 0.739. The consistency between the combined 3.0T HR-MRI and the serum MMP9 and AGR2HR levels and the postoperative pathologic results was the highest, with the Kappa value of 0.868 (all P＜0.05). The specificity (95.3%) and the positive predictive value (94.6%) of 3.0T HR-MRI combined the serum MMP9 and AGR2 levels for diagnosing the FIGO staging of the cervical cancer of the patients were significantly higher than those of 3.0T HR-MRI, the serum MMP9 level or the AGR2 level alone. The sensitivity (91.4%) and the negative predictive value (92.4%) of 3.0T HR-MRI combined the serum MMP9 and AGR2 levels for diagnosing the FIGO staging of the cervical cancer of the patients were significantly higher than those of the serum MMP9 level. The accuracy (93.4%) of 3.0T HR-MRI combined the serum MMP9 and AGR2 levels for diagnosing the FIGO staging of the cervical cancer of the patients was significantly higher than that of the serum MMP9 level and that of the serum AGR2 level (P＜0.05). Conclusion: 3.0T HR-MRI combined with THE serum MMP9 and AGR2 levels for the FIGO staging of the cervical cancer of the patients has diagnostic higher value.
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