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| Analysis of the gestational hypothyroidism situation and thyroid function of pregnant women with severe preeclampsia and their influence on the pregnancy outcomes and the neonates |
| Yuncheng Central Hospital, Yuncheng, Shanxi Province, 044000 |
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Abstract To investigate the role of gestational hypothyroidism and thyroid function changes of pregnant women in their severe preeclampsia occurrence, and to study their influence on the pregnancy outcomes and the neonates of the women. Methods: 80 pregnant women with severe preeclampsia(in group A), 80 pregnant women with mild preeclampsia(in group B), and 80 healthy pregnant women who underwent physical examinations(in group C) were selected as research subjects from January 2020 to December 2022. The thyroid function and the thyroid related antibodies of these women were tested. The correlation between the different thyroid functions of the women and their severity of preeclampsia was analyzed. The influences of hypothyroidism and thyroid function changes of the women on their pregnancy outcomes and the outcomes of their perinatal infant were also analyzed. Results: The serum thyroid stimulating hormone level(5.7±1.3 mIU/L) of the women in group A was significantly higher than that(3.5±0.9 mIU/L) of the women in group B and that(3.4±0.8 mIU/L) of the women in group C. The levels of free triiodothyronine(2.9±0.7 pmol/L) and free thyroxine(9.5±1.9 pmol/L) of the women in group A were significantly lower than those(4.3±0.8 pmol/L and 12.8±2.3 pmol/L) of the women in group B and those(4.5±0.9 pmol/L and 13.0±2.2) of the women in group C. The positive rates of thyroid peroxidase antibody(47.5%) and thyroglobulin antibody(36.3%) of the women in group A were significantly higher than those(10.0% and 6.3%) of the women in group B and those(8.8% and 5.0%) of the women in group C(all P<0.05). The incidences of the placental abruption, the premature delivery, the low birth weight, the perinatal asphyxia, the jaundice and the hypocalcemia of the women in group A were significantly higher than those of the women in group B and those of the women in group C(P<0.05), but which of the women had no significant different between group B and group C(P>0.05). Conclusion: The gestational hypothyroidism and the changes of thyroid function during pregnancy of the pregnant women may be one of the risk factors of their severe preeclampsia occurrence, and which can increase the risks of adverse pregnancy and perinatal infant outcomes. It is suggested that the thyroid function of the women with high-risk pregnancy should be monitored regularly and the herapeutic regimen of the women should be adjusted in time to reduce the incidence of complications.
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