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Abstract To study the values of the parameters of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of elderly patients with cervical cancer for differential diagnosing their pathological classification and pathological grading. Methods: 86 elderly patients with cervical cancer found during the physical examination from January 2019 to June 2022 were selected in this study. The magnetic resonance imaging T1WI, T2WI, IVIM-DWI, and DCE-MRI sequences were used for measuring the values of the parameters of the patients, such as apparent diffusion coefficient (ADC), slow diffusion coefficient (D), fast diffusion coefficient (D*), and perfusion fraction (f), volume transfer constant (Ktrans), rate constant (Kep), and volume fraction (Ve). Receiver operating characteristic (ROC) curve was used to analyze the values of these parameters of the patients for differential diagnosing their pathological classification and pathological grading of the cervical cancer. Results: The values of ADC and D of the elderly patients with squamous cell carcinoma were significantly lower than those of the elderly patients with non-squamous cell carcinoma, while the values of D*, f, Ktrans, and Kep of the elderly patients squamous with squamous cell carcinoma were significantly higher (P<0.05). The values of ADC and D of the elderly patients with poorly differentiated squamous cell carcinoma were significantly lower than those of the patients with moderately and well-differentiated squamous cell carcinoma, while the values of D*, Ktrans, and Kep of the patients with poorly differentiated squamous cell carcinoma were significantly higher (P<0.05). The area under the curve (AUC) of the values of ADC, D, D*, f, Ktrans, and Kep of the elderly patients for differential diagnosing their cervical squamous cell carcinoma were 0.688, 0.856, 0.770, 0.592, 0.771, and 0.805, respectively. The AUC, the sensitivity, and the specificity of the combined values of ADC, D, D*, f, Ktrans, and Kep of the elderly patients parameters for diagnosing their cervical squamous cell carcinoma were 0.948, 95.5%, and 94.4%, respectively. The AUC of the values of ADC, D, D*, Ktrans, Kep, and Ve of the elderly patients for differential diagnosing their moderately and well-differentiated cervical squamous cell carcinoma were 0.696, 0.716, 0.586, 0.642, 0.704, and 0.746, respectively. The AUC, the sensitivity, and the specificity of the combined values of ADC, D, D*, Ktrans, Kep, and Ve of the elderly patients for diagnosing their moderately and well-differentiated cervical squamous cell carcinoma were 0.900, 97.6%, and 75.0%, respectively. Conclusion: The values of IVIM-DWI and DCE-MRI parameters of the elderly patients with different pathological classification and pathological grading of cervical squamous cell carcinoma are differences, and the combined valuese of the IVIM-DWI and DCE-MRI parameters of the patients can provide the reference informations for differential diagnosing their pathological nature of the cervical cancer.
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