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| Study on co-crystal of nomegestrol acetate and vanillic acid |
| 1.The Comprehensive Service Center of Tianjin Commission of Health, Tianjin, 300131；2. National Research Institute for Family Planning |
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Abstract To investigate the structure and the stability of nomegestrol acetate co-crystal systematically. Methods: The nomegestrol acetate - vanillic acid co-crystal was designed and synthesized in the laboratory, and the obtained structure was characterized by powder X-ray diffraction (PXRD)，thermal gravimetric analysis (TG), differential scanning calorimetry (DSC), and infrared spectroscopy (IR). And the stability of nomegestrol acetate co-crystal was further investigated. Results: The structural characterization showed that the normegestrel acetate-vanillic acid co-crystal had been prepared successfully, and the stability studies showed that the normegestrel acetate-vanillic acid co-crystal had better stability. Conclusion: The co-crystal of the normegestrel acetate-vanillic acid has better physical stability, and which is the potential medicinal solid form.
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