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| Effect of color Doppler ultrasound combined with real time shear wave elastography for differential diagnosing breast cancer and benign breast nodules |
| 1. Graduate School of Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang Province, 310053；2. The Fourth Affiliated Hospital, School of Medicine, Zhejiang University |
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Abstract To analyze the value of high frequency color Doppler ultrasound (CDFI) combined with real time shear wave elastography (RT-SWE) for differential diagnosing breast cancer and benign breast nodules. Methods: 118 patients with breast tumor were selected and divided into group A (64 cases with breast cancer) and group B (54 cases with benign breast nodules) according to their pathological results from Jan. 2019 to Dec. 2021. The patients in both groups received CDFI and RT-SWE examinations. The breast imaging reporting, the grading of data system (BI-RADS), and the ultrasound signs by CDFI examination, and the modulus of elasticity by RT-SWE examinations of the patients were compared between the two groups. The coincidence rate of the CDFI examination, the RTSWE examination, and the combined examinations of CDFI and RT-SWE for differential diagnosing breast cancer and benign breast nodules was analyzed. The value of the CDFI examination, the RT-SWE examination, and the combined examinations of CDFI and RT-SWE for differential diagnosing breast cancer and benign breast nodules were analyzed by receiver operating characteristic (ROC) curve. Results: The breast cancer grading of BI-RADS by CDFI examination of the patients in group B was significantly higher than that of the patients in group A, and the rates of the posterior attenuation, the aspect ratio ≥1, the low or very low internal echo, the edge irregularity, the microcalcification, and the solid internal structure by CDFI examination of the patients in group B were significantly lower than those of the patients in group A. The values of average modulus of elasticity (Emean), maximum modulus of elasticity (Emax), and minimum modulus of elasticity (Emin) by RT-SWE examination of the patients in group B were significantly lower than those of the patients in group A (all P＜0.05). The positive and negative prediction rates for the breast cancer and the breast benign nodules of the patients by CDFI examination were 80.0% and 77.4%, which by RTSWE examination were 87.3% and 83.6%. The positive and the negative prediction rates of CDFI combined with RT-SWE examinations for the breast cancer and the breast benign nodules of the patients were 93.9% and 96.2%. The areas under the curve of the CDFI examination, the RT-SWE examination, and the CDFI combined with RT-SWE examinations for diagnosing the breast cancer and the breast benign nodules were 0.786, 0.849, and 0.913, respectively. Conclusion: The CDFI combined with RT-SWE examinations for differential diagnosing breast cancer and benign breast nodules has high reference value in clinic.
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