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| Correlation between the serum miR-152 and miR-375 levels of women with early onset preeclampsia and their pregnancy outcomes |
| Daxing District People's Hospital of Beijing, Beijing, 102600 |
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Abstract To investigate the correlation between the serum miR-152 and miR-375 levels of pregnant women with early onset preeclampsia and their pregnancy outcomes. Methods: 88 pregnant women with early onset preeclampsia (in study group) and 78 healthy pregnant women (in control group) who had delivered from August 2017 to August 2019 were collected retrospectively. The general data of the women was compared between the two groups. According to the pregnancy outcomes of the women in the study group after followed up, the women were divided in group A (women with normal pregnancy outcomes) and group B (women with adverse pregnancy outcomes). The relative expression levels of serum miR-152 and miR-375 of the women were detected by real-time fluorescent quantitative PCR. Cox regression analysis was used to analyze the influencing factors of the adverse pregnancy outcome of the women with early onset preeclampsia. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of the serum miR-152 and miR-375 levels of the women with early onset preeclampsia for their adverse pregnancy outcomes. Results: The expression levels of miR-152(7.56±2.42) and miR-375(4.72±1.02) of the women in the study group were significantly higher than those (1.00±0.26 and 1.10±0.25) of the women in the control group (all P＜0.05). There were 26(29.6%) women in group B. The levels of serum miR-152 and miR-375(9.39±2.78 and 5.98±1.53) of the women in group B were significantly higher than those (6.79±2.06 of 4.19±0.51) of the women in group A (all P＜0.05). The values of systolic blood pressure and diastolic blood pressure, and the levels of serum miR-152 and miR-375 of the women in the study group were the independent risk factors of their adverse pregnancy outcomes. The area under the curve (AUC) of the serum miR-152 level and the miR-375 level of the women with early-onset preeclampsia for evaluating their adverse pregnancy outcomes were 0.769 and 0.829, the cutoff values of which were 7.88 and 4.99, the sensitivity of which were 73.1% and 69.2%, and the specificity of which were 72.6% and 98.4%. The AUC, the sensitivity, and the specificity of the combined of the miR-152 and miR-375 levels of the women with early-onset preeclampsia for evaluating their adverse pregnancy outcomes were 0.921, 80.8%, and 96.8%, respectively. Conclusion: The levels of serum miR-152 and miR-375 of the pregnant women with early-onset preeclampsia can be used as the indexes to evaluate their adverse pregnancy outcomes.
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