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| Levels of plasma placental growth factor and microRNA of pregnant women with preeclampsia during the first trimester of pregnancy and their predictive value for the risk of preeclampsia |
| Shanxi Fenyang Hospital, Lvliang, Shanxi Province, 032200 |
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Abstract To analyze the expression of plasma placental growth factor (PIGF) and microRNA-240 (miRNA-240) of pregnant women with preeclampsia (PE) during the first trimester of pregnancy, and to construct the risk prediction model of PE. Methods: The clinical data of pregnant women who had been antenatal examination and delivery in hospital from January 2020 to June 2021 were collected. Among the women with PE in study group, 60 women with early onset PE were in group A and 70 women with later onset PE were in group B. 150 normal pregnant women were included in control group. The plasma PIGF and serum miRNA-204 levels of the women in the three groups were detected during 11-13+6 gestational weeks of their Down's syndrome screening. Receiver operating characteristic (ROC) curve was drawn to analyze the values of the plasma PIGF and serum miRNA-204 levels of the women for predicting their PE. Results: The level of plasma PIGF (136.98±16.78 pg/ml) of the women in the study group was significantly lower than that (179.58±20.13 pg/ml) of the women in the control group, and the level of the peripheral blood miRNA-240-5p (2.11±0.41) of the women in the study group was significantly higher than that (1.03±0.32) of the women in the control group (P＜0.001), but both of which of the women had no significant differences between group A and group B (P＞0.05). In the study group, the plasma PIGF level of the women was negatively correlated with the relative expression of their serum miRNA-204 (P＜0.001). ROC curve showed that the efficacy of the plasma PIGF and the serum miRNA-204 levels of the women during the first trimester of pregnancy for predicting their PE were better, and the area under the curve (AUC) of which were 0.798 and 0.809. In Logistic regression analysis, X1=PIGF, X2=miRNA-204, the regression equation of predicting PE value was obtained. The AUC of the combined plasma PIG and serum miRNA-204 levels of the women for predicting their PE was 0.876, which was significantly higher than that of the plasma PIG level or the serum miRNA-204 level alone. Conclusion: The plasma PIGF level of the pregnant women with PE during the first trimester of pregnancy is abnormally decreased, and the serum miR-204 level is abnormally increased, and both of which has good predictive efficacy for PE, and the combined plasma PIG and serum miRNA-204 levels of the women for predicting their PE has higher value.
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