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Abstract To analyze the effect of esketamine used for the improvement of vital signs and comfort of women in painless sugical abortion. Methods: From January 2021 to January 2023, 100 women who wanted painless sugical abortion were randomly divided into two groups (50 cases in each group). The women in the control group were given sufentanil 0.1 μg/kg combined with propofol 2 mg/kg injection intravenously, and the women in the observation group were given esketamine 0.1-0.2 mg/kg combined with propofol 2 mg/kg injection intravenously. The values of the anesthesia indexes, the vital signs, the degree of postoperative uterine contraction pain by VAS score, the postoperative comfort by GCQ score, and the adverse reactions rate of the women in the two groups were observed. Results: The anesthesia indexes values of the women in the observation group were significantly better than those of the women in the control group, and the vital signs of the women in the observation group after propofol intravenous injection and after the operation were significantly better than those of the women in the control group. The VAS scores of uterine contraction pain of the women in the observation group at 10min, 20min, 30min, and 60min after awakening were 2.98±0.50 points, 2.14±0.41 points, 2.00±0.35 points, and 1.35±0.16 points, respectively, which were significantly lower than those (3.47±0.53 points, 2.73±0.36 points, 2.42±0.27 points, and 2.00±0.24 points, respectively) of the women in the control group. The comfort GCQ scores of the women in the observation group at 10min, 20min, 30min, and 60min after awakening were 89.98±9.56 points, 94.72±11.68 points, 100.33±12.41 points, and 105.62±11.04 points, respectively, which were significantly higher than those (84.57±10.73 points, 88.69±12.59, 95.72±12.73, and 99.14±10.45 points, respectively) of the women in the control group. The incidence of adverse reactions (6.0%) was significantly lower than that (20.0%) of the women in the control group (P＜0.05). Conclusion: Esketamine combined with propofol used in painless sugical abortion of the women has good effect, which can improve their anesthetic indexes, promote their postoperative recovery, stabilize their vital signs, reduce their postoperative uterine contraction pain, improve their postoperative comfort, and reduce their adverse reactions, with better effectiveness and safety.
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