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| Effects of pancreatic kininogenase in vitro fertilization-embryo transfer on in the women with recurrent failure of intrauterine insemination by husband before |
| 1. Handan Central Hospital, Handan Hebei Province, 056001；2. The Seventh hospital of Handan, Hebei Province |
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Abstract To explore the effects of pancreatic kininogenase for treating the women with recurrent failure ofintrauterine insemination by husband before in vitro fertilization-embryo transfer (IVF-ET) on their pregnancy outcomes. Methods: A total of 192 women with repeated failure of intrauterine insemination by husband were selected and were divided into two groups (96 cases in each group) according to the random number table method from January 2016 to December 2020. The women in the control group were given vitamin E treatment for 3 months, and the women in the observation group were given pancreatic kininogenase treatment for 3 months. Then the women in both groups had been IVF-ET. The sperm quality of the spouses before and after treatment, the ovulation induction-related indicators, the development situation of the in vitro embryo, and the pregnancy outcomes of the women were compared between the two groups. Results: The semen volume and sperm concentration of the spouses of the women in the two groups after treatment had increased significantly, but which had no significant difference of the women between the two groups (P＞0.05). The rates of the forward motility sperm and the normal morphologic sperm of the spouses of the women in the two groups had increased significantly, and which of the spouses in the observation group were significantly higher than those of the spouses in the control group (P＜0.05). The DFI of the spouses in the two groups had decrease significantly, and which of the spouses in the observation group was significantly lower than that of the spouses in the control group (P＜0.05). There were no significant differences in the duration and the dosage of Gn used, and the endometrial thickness, the estradiol level on hCG day, and the numbers of oocytes retrieved and MII eggs of the women between the two groups (P＞0.05). The fertilization rate, the 2PN rate, the cleavage rate, the high -quality embryo rate, and the blastocyst formation rate of the women in the observation group were significantly higher than those of the women in the control group (P＞0.05). There was no significant difference in the abortion rate of the women between the two groups (P＞0.05). The clinical pregnancy rates of the fresh embryo transplantation and frozen embryo transplantation (90.9% and 75.7%) and the ratio of cumulative live birth to continued pregnancy (74.0%) of the women in the observation group were significantly higher than those (46.2%, 58.6%, and 45.8%) of the women in the control group (all P＜0.05). Conclusion: The pancreatic kininogenase for treating the women with recurrent intrauterine insemination failure by husband before IVF-ET can improve their clinical pregnancy rate, with shorter treatment time and lower treatment cost, which has clinical promotion value.
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