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| Efficacy of hysteroscopic polypectomy combined with doxycycline for treating patients with chronic endometritis and endometrial polyp and it influence on the pregnancy outcomes of these patients |
| 1. Lujiang County People's Hospital, Hefei, Anhui Province, 231500；2. Anhui Provincial Hospital of traditional Chinese Medicine |
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Abstract To explore the efficacy of hysteroscopic polypectomy combined with doxycycline for treating patients with chronic endometritis and endometrial polyp, and to study it influences on the pregnancy outcomes of these patients. Methods: The clinical data of 88 patients with chronic endometritis and endometrial polyp from January 2019 to January 2021 were collected. These patients were divided into study group (40 patients with doxycycline treatment) and control group (48 patients without doxycycline treatment) based on their treatment with doxycycline after hysteroscopic polyp removal. The distribution of intrauterine bacterial culture, the cure rate of endometritis, and the positive plasma cell count of membrane heparan sulfate proteoglycan ligand proteoglycan-1 (CD138) of the patients were compared between the two groups. The time of endometritis cure, the postoperative complications rate, the polyp recurrence situation, and the pregnancy outcomes within 6 months after chronic endometritis cure of the patients were counted. Results: The CD138 positive cells count (2.1±3.7) and the cure rate of chronic endometritis (89.6%) of the patients in the control group had no significantly different from those (3.2±3.2 and 75.0%) of the patients in the study group (P>0.05). The time of postoperative endometritis recovery (42.3±5.2d) of the patients in the control group was significantly less than that (56.5±32.3d) of the patients in the study group (P＜0.05). There were no significant differences in the detection rate of lactic acid bacteria and the postoperative complications rate of the patients between the two groups. The rate of endometrial polyps recurrence (10.0%) of the patients in the study group had no significantly different from that (6.3%) of the patients in the control group (all P>0.05). There were 35 patients with postoperative pregnancy in both groups, and there were no significant differences in the mode of delivery and the incidence of post-pregnancy abortion of the patients between the two groups (P>0.05). The clinical pregnancy rate (74.3%) of the patients in the control group was significantly higher than that (34.3%) of the patients in the study group, and the time from pregnancy preparation to pregnancy (80.5±55.7d) of the patients in the control group was significantly lower than that (120.6±68.6d) of the patients in the study group (P＜0.05). Conclusion: The polyp resection for treating the patients with chronic endometritis and endometrial polyps has better cured efficacy, but which combined with the postoperative treatment of doxycycline can delay the postoperative recovery, decrease the postoperative pregnancy rate, and delay the postoperative pregnancy.
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