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| Efficacy and safety of afentanil combined with propofol used in painless abortion |
| Dongyang People's Hospital, Dongyang, Zhejiang Province, 322100 |
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Abstract To investigate the efficacy and safety of afentanil combined with propofol used in painless abortion. Methods: The women who planned to undergo painless abortion in hospital were selected as the research objects from March 1, 2022 to March 1, 2022. These women were randomly divided into experimental group (women with alfentanil combined with propofol for anesthesia) and control group (women with fentanyl combined with propofol for anesthesia). The onset time of intravenous anesthesia, the dosage of propofol used during anesthesia, the time of consciousness recovery, and the time of discharge of the women in the two groups were observed. The changes of the values of heart rate (P), mean arterial pressure (MAP), and oxygen saturation (SpO2) of the women in the two groups before anesthesia induction (T0), 5 min after anesthesia induction (T1), 5 min after the beginning of surgery (T2), 10 min after the completion of surgery (T3), and when leaving the operating room (T4) were observed. The visual analogue scale (VAS) score was used to evaluate the degree of pain of the women in the two groups at 5 min and 10 min after administration. The adverse reactions during the induction period of anesthesia of the women in the two groups were recorded during the anesthesia induction. Results: The onset time of intravenous anesthesia (63.2±7.7s) of the women in group A was significantly faster than that (70.6±8.7s) of the women in group B. The dosage of propofol used during anesthesia (1.8±0.2 mg/kg) of the women in group A was significantly lower than that (2.2±0.3 mg/kg) of the women in group B. The time of the consciousness recovery (4.6±1.3min) of the women in group A was significantly shorter than that (6.8±2.2min) of the women in group B. The time to discharge from hospital (38.3±4.7 min) of the women in group A was significantly less than that (45.4±5.2 min) of the women in group B. The incidences of cough (2.3%), hypotension (3.4%), and nausea (5.7%) of the women in group A were significantly lower than those (5.7%, 6.8%, and 9.1%) of the women in group B. The VAS score at 5min (4.25±1.62 points) and at 10min (6.52±2.65 points) after administration of the women in group A were all significantly lower than those (4.82±2.24 points and 7.56±1.27 points) of the women in group B (all P<0.05). There were no significant differences in the values of hemodynamic indexes of the women at different time-point between the two groups (P>0.05). Conclusion: Compared with those of fentanyl or alfentanil combined with propofol used in painless abortion of the women has better anesthesia effect, with rapidly onset of anesthesia, and which can stable the intraoperative hemodynamics, shorter the postoperative recovery time, decrease the incidence of adverse reactions, shorter the hospital stay time, and increase the satisfaction of the women. Alfentanil combined with propofol has provide new ideas and strategies for anesthesia in painless artificial abortion of the women.
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