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| Dose-effect on the anesthetic effect and safety of etomidate combined with propofol of patients during laparoscopic total hysterectomy |
| 1.Jieshou Hospital of Traditional Chinese Medicine, Fuyang, Anhui Province, 236502; 2.Taihe County People's Hospital, Fuyang |
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Abstract To study the anesthetic effect and safety of the different dosages of etomidate combined with propofol of patients during laparoscopic total hysterectomy. Methods: The clinical data of 80 patients who had accepted laparoscopic total hysterectomy in the hospital from January 2019 to March 2022 were selected in this study. According to the different ratios of propofol and etomidate, these patients were divided into group A(32 patients with 1.5 mg/kg propofol and 0.075 mg/kg etomidate), group B(23 patients with 1.0 mg/kg propofol and 0.15 mg/kg etomidate) and group C(25 patients with 0.5 mg/kg propofol and 0.225 mg/kg etomidate). The disappearance time of eyelid reflex, the awakening time and the extubation time of the patients were compared among the three groups. The values of heart rate, mean arterial pressure(MAP) and bispectral index(BIS) of the patients at 1 min before anesthesia induction(T0), before intubation(T1), at 1 min after intubation(T2), at 3 min after intubation(T3) and at 5 min after intubation(T4), and the incidence of adverse events of the patients were compared among the three groups. Results: The disappearance time of eyelid reflex(1.94±0.28 min) of the patients in group C was significantly longer than that(1.70±0.24 min) of the patients in group A and that(1.94±0.28 min) of the patients in group B(P<0.05). There were no significant differences in the recovery time, the extubation time and the HR value of the patients in different time point among the three groups(P>0.05). The MAP value of the patients in group A at T2 and at T3(84.80±9.17 mmHg and 69.94±6.52 mmHg) were significantly lower than those(93.46±8.12 mmHg and 76.05±6.44 mmHg) of the patients in group C(P<0.05), and there were no significant difference in the MAP value of the patients at T0, T1 and T4 among the three groups(P>0.05). There was no significant difference in the BIS value of the patients at T0 and T1 among the three groups(P>0.05), and the BIS value of the patients in group A at T2-T4 was the highest(P<0.05). The incidence of myoclonus(25.0%) of the patients in group A was significantly lower than that(60.0%) of the patients in group C(P<0.05). There was no significant difference in the other adverse events rate of the patients among the three groups(P>0.05). Conclusion: The anesthetic effect of 1.5 mg/kg propofol and 0.075 mg/kg etomidate used during laparoscopic total hysterectomy of the patients is more ideal, which can maintain their hemodynamic balance, and with the lower probability of the adverse events.
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