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| Effects of nalbuphine combined with sufentanil used for analgesia after cesarean section of women on their sedation, pain, and prognosis |
| Maanshan Maternal and Child Health Care Hospital, Maanshan, Anhui Province, 243000 |
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Abstract AbstractObjective: To investigate the effects of nalbuphine combined with sufentanil used for analgesia after cesarean section of women on their scores of Ramsay and visual analogue scale (VAS), and their prognosis. Methods: 80 women who had received cesarean section were included and were randomly divided into observation group (40 women were given sufentanil combined with nalbuphine for analgesia by combined spinal-epidural anesthesia) and control group (40 women were given sufentanil for analgesia by combined spinal-epidural anesthesia) from January 2019 to December 2021. The postoperative situation, the scores of VAS and Ramsay, the adverse reactions rate, and the quality of life of the women in the two groups were observed. The correlation between the maternal autonomously urination time and the time to the first getting out of bed of the women and their VAS score was analyzed. The correlation between the prognostic quality of life of the women and their VAS score was also analyzed. Results: Immediately after surgery, the values of SBP, DBP, and HR of the women in the two groups had increased significantly, but which of the women had no significant difference between the two groups (P>0.05). The time of spontaneous urination (17.23±2.26h) and the time of the first getting out of bed (11.32±2.56 h) of the women in the observation group were significantly lower than those (25.37±1.83h and 15.19±2.37h) of the women in the control group. The effective analgesic time (41.33±3.18 h) of the women in the observation group was significantly higher than that (29.62±1.87 h) of the women in the control group (all P<0.05). The VAS score of the women in the observation group in 12h (2.12±0.22 points) or in 24h (2.35±0.24 points) after surgery was significantly lower than that (3.68±0.25 points or 3.44±0.33 points) of the women in the control group (P<0.05). There was no significant difference in the Ramsay score of the women between the two groups (P>0.05). There was no significant difference in the total incidence of adverse reactions (7.5% vs.12.5%) of the women between the two groups (P>0.05). In 3 months of follow-up after surgery, the quality-of-life score (83.29±4.78 points) of the women in the observation group was significantly higher than that (73.52±7.33 points) of the women in the control group (P<0.05). Pearson analysis showed that the time of spontaneous urination of the women was negatively correlated with the time of their first getting out of bed, and was positively correlated with their VAS score (all P<0.05). Conclusion: Application of nalbuphine combined with sufentanil for analgesia of the women after cesarean section can effectively improve their clinical stress response and pain degree, and can effectively improve their prognosis and quality of life, and with higher clinical safety.
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