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| Effects of insulin aspart combined with different doses of vitamin D for treating pregnant women with gestational diabetes mellitus on their glucolipid metabolism, insulin resistance, and delivery outcomes |
| 1.Guoyang Branch of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Bozhou, Anhui Province, 233600； 2.The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui Province |
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Abstract To explore the effects of insulin aspart combined with different doses of vitamin D for treating pregnant women with gestational diabetes mellitus (GDM) on their glucolipid metabolism, insulin resistance, and delivery outcomes. Methods: 93 pregnant women with GDM who had been treated in the hospital were divided into group A (46 women treated with low-dose of vitamin D 10 U/time for 1 month) and group B (47 women treated with high-dose of vitamin D 30U/time) according to the random number table method from January 2018 to January 2022. The changes of glycemic and lipid metabolism indexes and insulin resistance of the women in the two groups after treatment were observed. The delivery outcomes of the women in the two groups were followed up. Results: After treatment, the levels of fasting blood glucose (5.29±0.76 mmol/L), the 2h post-meal blood glucose (6.64±0.82 mmol/L), and the HBA1c (5.11±0.34 %) of the women in group B were significantly lower than those of the women in group A. After treatment, the levels of fasting insulin (11.89± 1.04mU/L) and insulin resistance index (3.24±0.41) of the women in group B were significantly lower than those of the women in group A. After treatment, the β-cell function index (0.98± 0.13mmol/L) of the women in group B was significantly higher than that of the women in group A. The levels of total cholesterol (3.21±0.75 mmol/L), triglyceride (3.03±0.86 mmol/L), and low-density lipoprotein (3.12±0.76), and the incidences of cesarean section (17.0%), premature delivery (23.4%), premature rupture of membranes (12.8%), and macrosomia (8.5%) of the women in group B were significantly lower than those of the women in group A (all P<0.05). Conclusion: Insulin aspart combined with high-dose vitamin D is more conducive to the improvements of blood glucose and blood lipids of the patients with GDM, and which can reduce the insulin resistance of the women, and has lower the maternal-infant complications rate.
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