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| Indexes of coagulation function and fibrinolytic system of women with gestational diabetes mellitus during the third trimester of pregnancy and their influence on the adverse pregnancy outcomes |
| Mianyang People's Hospital, Mianyang, Sichuan Province, 621000 |
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Abstract To explore the indexes of coagulation function and fibrinolytic system of pregnant women with gestational diabetes mellitus (GDM) during the third trimester of pregnancy, and to study their influence on the adverse pregnancy outcomes of these women. Methods: The clinical data of 170 pregnant women during the third trimester of pregnancy and who had delivered in hospital from December 2020 to February 2022 were analyzed retrospectively. These women were divided in observation group (85 women with GDM) and in control group (85 women without GDM). The coagulation function and fibrinolytic system indexes of the women in the two groups were detected. The pregnancy outcomes of the women in the two groups were counted. The correlation between the coagulation function and fibrinolytic system indexes of the women and their pregnancy outcomes was analyzed. Results: The prohemase time (PT) value (11.12±1.55 s), the activated partial thrombin time (APTT) value (25.64±2.97s), and the fibrinogen (FIB) level (4.29±0.81g/L) of the women in the observation group were significantly lower than those (14.56±2.87s, 37.54±4.26s, and 3.09± 0.34g/L) of the women in the control group. The fibrin degradation products (FDP) value (3.10±0.39 mg/L) and D dimer (DD) level (0.89±0.09 g/L) of the women in the observation group were significantly higher than those (2.27±0.24 mg/L and 0.67±0.07 g/L) of the women in the control group. The incidence of adverse pregnancy outcomes (41.2%) of the women in the observation group was significantly higher than that (12.9%) of the women in the control group (all P＜0.05). Logistic regression analysis showed that the PT ≤10.8s, the APTT ≤25.3s, the FIB level ≤4g/L, the DD level >0.91g/L, the FDP level of 2.78mg/L, and the fasting blood glucose level >7.0mmol/L of the women with GDM during the third trimester of pregnancy were the risk factors of their adverse pregnancy outcomes (P＜0.05). Conclusion: The coagulation function and fibrinolytic system indexes of the women with GDM during the third trimester of pregnancy are abnormally, and the adverse pregnancy outcomes of these women increase. The abnormal levels of the PT, APTT, FIB, DD, FDP, and fasting blood glucose of the women with GDM are all the risk factors of their adverse pregnancy outcomes, which indicate that the clinical targeted intervention should be taken on the abnormal levels of the PT, APTT, FIB, DD, FDP, and fasting blood glucose of the women with GDM, so as to improve the pregnancy outcomes of the women.
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