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| Expressions and clinical significances of the serum amyloid A and progranulin of obese women with polycystic ovary syndrome |
| Taizhou Hospital of Integrated Traditional Chinese and Western Medicine, Zhejiang Province, 317523 |
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Abstract To investigate the expressions and clinical significances of the serum amyloid A (SAA) and progranulin (PGRN) of obese women with polycystic ovary syndrome (PCOS). Methods: A total of 100 obese women with PCOS who were diagnosed and treated in hospital were included in group A and 100 women with PCOS and normal body mass index were included in group B from April 2021 to April 2022. 100 obese women without PCOS were included in group C during the same period. The levels of serum SAA and PGRN of the women in the three groups were detected. Pearson analysis was used to analyze the correlation between the levels of serum SAA and PGRN of the women and their laboratory indexes levels. Logistic regression was used to analyze the influencing factors of the PCOS occurrence of the obese women. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of the levels of serum SAA and PGRN of the obese women for their PCOS occurrence. Results: The levels of total cholesterol (TC), three acyl glycerin (TG), low density lipoprotein (LDLC), fasting insulin (FINS), HOMA IR, SAA, and PGRN of the women in group A were significantly higher than those of the women in group B and in group C, and the high-density lipoprotein (HDL-C) of the women in group A was significantly lower than that of the women in group B and in group C (P＜0.05), and all of which had no significant differences between group B and group C (P＞0.05). The SAA level of the women in group A were positively correlated with the levels of their serum PGRN, TC, TG, LDL-C, and FINS, and their HOMA-IR value, but was negatively correlated with their HDL-C level. The PGRN level of the women in group A were positively correlated with the levels of their serum TC, TG, LDL-C, and FINS, and their HOMA-IR value, but was negatively correlated with their HDL-C level (all P＜0.05). The high levels of TG, LDL-C, FINS, HOMA-IR, SAA, and PGRN of the obese women were all the independent risk factors of their PCOS occurrence, and the high level of HDL-C of the obese women was the independent protection factor of their PCOS occurrence (all P＜0.05). The area under curve (AUC) of the serum SAA level, the PGRN level, and the combined of the levels of SAA and PGRN of the obese women for predicting their PCOS occurrence were 0.763, 0.762, 0.852, respectively, and which of the combined levels of SAA and PGRN of the women for predicting their PCOS occurrence was significantly higher than that of the SAA level or the PGRN level alone (P＜0.05). Conclusion: The SAA and PGRN levels of the obese women with PCOS increase，which are all correlated with their levels of TC、TG, LDL-C, HDL-C, and FINS, and their HOMA-IR value, and are the independent risk factors of their PCOS occurrence. The combined levels of SAA and PGRN of the obese women for predicting their PCOS occurrence has certain values.
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