|
|
|
| Levels of serum histone deacetylase 2 and brain derived neurotrophic factor of pregnant women with gestational diabetes mellitus and their values for predicting the adverse neonatal outcomes |
| Beijing Daxing District People's Hospital, Beijing, 102600 |
|
|
|
|
Abstract To investigate the levels of serum histone deacetylase 2 (HDAC2) and brain derived neurotrophic factor (BDNF) of pregnant women with gestational diabetes mellitus (GDM) and their values for predicting the adverse neonatal outcomes of the women. Methods: The clinical data of 120 pregnant women with GDM from December 2020 to December 22 were collected and these women were included in observation subjects. According to the neonatal outcomes, these women were divided into group A (75 cases with normal neonatal outcomes) and group B (45 cases with adverse neonatal outcomes). 120 healthy pregnant women were included in control group during the same period. The levels of serum HDAC2 and BDNF of the women in these groups were detected, and the correlation between which and the glycolipid metabolism indexes of the women was analyzed. The diagnostic values of the levels of serum HDAC2 and BDNF of the women with GDM for their adverse neonatal outcomes were also analyzed. Results: The levels of serum HbA1c, FBG, FINS, TG, and TC, and the HOMA IR value of the women in the observation group were significantly higher than those of the women in the control group. The level of serum HDAC2 (32.25±6.53 ng/ml) of the women in the observation group was significantly higher than that (18.56±4.63 ng/ml) of the women in the control group, but the level of BDNF (1.32±0.35 ng/ml) of the women in the observation group was significantly lower than that (1.95±0.42 ng/ml) of the women in control group (P<0.05). Correlation analysis showed that the level of serum HDAC2 of the women with GDM was positively correlated with their levels of HbA1c, FBG, FINS, TG, and TC, and HOMA IR value. The BDNF level of the women with GDM was negatively correlated with their levels of HbA1c, FBG, FINS, TG, and TC, and HOMA IR value (all P<0.05). The serum HDAC2 level of the women in group B was significantly higher than that of the women in group A, and the serum BDNF level of the women in group B was significantly lower (all P<0.05). The area under the curve, the sensitivity, and the specificity of the combined serum HDAC2 and BDNF levels of the women with GDM for diagnosing their adverse neonatal outcomes were 0.931, 91.1%, and 82.7%, respectively. The diagnostic efficacy of the combined serum HDAC2 and BDNF levels of the women was significantly higher than that of the serum HDAC2 level and the BDNF level alone (P<0.05). Conclusion: The serum HDAC2 level of the women with GDM is increased and the BDNF level is decreased abnormally, and both of which are related to their glucolipid metabolism indexes, and which may be used as the markers to predict the adverse neonatal outcomes of the women.
|
|
|
|
|
|
|
|
|
