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| Analysis of the levels of CD4+T cells, CD8+T cells, and Th1/Th2 of patients with different types of human papillomavirus infections |
| Guang'an City People's Hospital, Guang'an, Sichuan Province, 638000 |
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Abstract To investigate the correlation between the different types of human papillomavirus (HPV) infections of patients and their expressions of CD4+T cells, CD8+T cells, and Th1/Th2 in peripheral blood. Methods: The clinical data of 172 patients with HPV infections from July 2021 to June 2022 were collected. The HPV typing of these patients with HPV infection had been performed. The levels of CD4+T cells, CD8+T cells, and Th cytokines, interleukin (IL) 2, interferonγ(IFNγ), IL4, and IL10 in peripheral blood of these patients were detected. The levels of inflammatory factors in peripheral blood were compared between the patients with high risk HPV infection and the patients with low risk HPV infection, and between the patients with multiple HPV infection and the patients with single HPV infection. Results: Among 172 patients with HPV infection, 80.2% patients were high risk HPV infection and 19.8% patients were low risk HPV infection, and 64.5% patients were single HPV infection and 35.5% were multiple infection. The most infection of high-risk HPV was HPV 16, and then followed by HPV 52 and HPV 58, and the most infection of low-risk HPV was HPV 61. The CD4+/CD8+ ratio, and the levels of CD4+T cells, IL2, and IFN γin peripheral blood of the patients with high risk HPV infection were significantly lower than those of the patients with low risk HPV infection, and the level of CD8+T cells in peripheral blood and the levels of serum IL-4 and IL-10 of the patients with high risk HPV infection were significantly higher. The CD4+/CD8+ ratio, and the levels of CD4+T cells, IL-2, and IFN γof the patients with multiple HPV infection were significantly lower than those of the patients with single HPV infection, and the CD8+T cells level and the levels of serum IL-4 and IL-10 of the patients with multiple HPV infection were significantly higher (all P<0.05). Conclusion: The expressions of CD4+T cells and CD8+T cells levels of the patients with different types of HPV infections have different. The patients with high-risk HPV infection have lower expressions of CD4+T cells, CD4+/CD8+, and Th1 cytokines, and higher expressions of CD8+T cells and Th 2 cytokines, and which is more obvious in the patients with multiple HPV infection.
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