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| Effect of anti-HPV biological protein dressing for treating patients with cervical precancerous lesions complicated with high-risk human papillomavirus infection |
| 1.Suixi County Hospital of Traditional Chinese Medicine, Suixi, Anhui Province, 235100; 2. Anhui Huaibei Miners General Hospital |
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Abstract To compare the efficacy of Baofukang suppository, Xinfuning, and anti-HPV biological protein dressing for treating patients with cervical precancerous lesions complicated with high-risk human papillomavirus(HR-HPV) infection. Methods: A total of 212 patients with cervical precancerous lesions complicated with HRHPV infection were selected and were randomly divided into four groups(53 cases in each group) from January 2019 to May 2021. The patients in group A were treated with Baofukang suppository by vagina, the patients in group B were treated with Xinfuning by vagina, the patients in group C were treated with antiHPV biological protein dressing, and the patients in D were not given any special treatment except to regular follow-up. The HPV negative conversion rate and the adverse reactions rate of the patients were compared among the four groups. Results: In 1, 3, 6 and 12 months after drug withdrawal, the rate of HPV negative conversion and effectiveness of TCT of the patients in group A(42.9%), in group B(47.9%), or in group C(66.7%) was significantly higher than that(9.8%) of the patients in group D, and which of the patients in group C was significantly higher than that of the patients in group A or in group B(all P＜0.05), but which of the patients in group A had no significantly different from that of the patients in group B(P>0.05). The reversal rate by colposcopy of the patients in group A(18.2%), in group B(20.0%), or in group C(35.3%) was significantly higher than that(0) of the patients in group D, and which of the patients in group C was significantly higher than that in group A or in group B(all P＜0.05). There was no any patient with serious adverse reactions in the four groups. Conclusion: Baofukang suppository, Xinfuning, and anti-HPV biological protein dressing for treating the patients with cervical precancerous lesions complicated with HRHPV infection have certain efficacy, and the efficacy of anti-HPV biological protein dressing is better than that of Baofukang suppository or Xinfuning.
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