|
|
|
| Research progress of clock genes in reproductive system |
| 1.Zunyi Medical University, Guizhou Province, 563006；2. National Research Institute for Family Planning, Beijing；3.Graduate School Peking Union Medical College, Beijing；4.Xinxiang Medical College |
|
|
|
|
Abstract Biological circadian rhythm, also known as circadian rhythm, is an intracellular mechanism that regulates most physiological and metabolic activities of the body with a cycle of about 24 hours and is produced by the body to adapt to changes in the external environment. Circadian rhythm is the central regulator of human health. It plays a very important role in the developments of nerve, cardiovascular, and other organs. Circadian rhythm disorders are associated with the developments of diabetes, metabolic diseases, tumor, and many other diseases. At present, more and more studies have shown that circadian rhythm also affects the developments of testis, ovaries, follicles, and germ cells, so abnormal circadian rhythm can also lead to the occurrence of diseases related to the reproductive system. The maintenance of circadian rhythm is mainly regulated by core clock genes. In this paper, the expression dynamics of core clock gene in related tissues of reproductive system and its regulation of reproductive function were summarized. Understanding of the clock genes how to regulate the relationship between reproductive functions will provide idea and targets for the development of the new clock-oriented treatment strategies, and will help to further improve the therapeutic effect of the reproductive system related diseases caused by abnormal clock genes.
|
|
|
|
|
|
|
|
|
