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Abstract To investigate the levels of serum C1q/tumor necrosis factor related protein 6 (CTRP6)and soluble tumor necrosis factor receptor (sTNFR)-Ⅱ of pregnant women with preeclampsia (PE), and to study their diagnostic values for PE. Methods: The clinical data of 148 pregnant women with confirmed PE (in group A)from June 2021 to June 2022 were selected. These women were divided group A1 (85 cases with mild PE)and group A2 (63 cases with severe PE)according to the severity of PE. 75 healthy pregnant women were selected in group B during the same period. The expression levels of serum CTRP6 and sTNFR-Ⅱ of the women in these groups were determined by enzyme-linked immunosorbent assay (ELISA). Pearson method was used to analyze the correlation between the serum CTRP6 level of the women with PE and the level of their sTNFR-Ⅱ. Receiver operating characteristic (ROC)curve was used to analyze the diagnostic value of CTRP6 and sTNFR-Ⅱ for the occurrence and development of PE. Results: The levels of urinary protein quantity, ALT, Fib, and Cr, the values of systolic and diastolic blood pressure, and the serum CTRP6 and sTNFR-Ⅱ levels of the women in group A2, group A1, and group B had decreased gradually, and the PT value of the women in group A2, group A1, and group B had increased gradually (all P＜0.05). Correlation analysis showed that the serum CTRP6 level of the women with PE was positively correlated with their sTNFR-Ⅱ level (r=0.354, P＜0.001). ROC curve analysis showed that the area under the curve (AUC)of the CTRP6 level combined with the sTNFR-Ⅱ level of the women for diagnosing their PE (0.975)was significantly higher than that of the CTRP6 level and the sTNFR-Ⅱ level alone, and the sensitivity and the specificity of which were 79.7% and 92.3%. The AUC, the sensitivity, and the specificity of the CTRP6 level combined with the sTNFR-Ⅱ level for diagnosing severe PE was 0.925, 39.7%, and 98.8%, respectively, and which were significantly higher than that of the CTRP6 level and the sTNFR-Ⅱ level alone (all P＜0.001). Conclusion: The levels of serum CTRP6 and sTNFR-Ⅱ of the pregnant women with PE increase abnormally, both of which are related to the severity of PE, and the diagnostic efficacy of the combined levels of serum CTRP6 and sTNFR-Ⅱ for PE is higher.
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