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| Expressions and clinical significances of silent information regulator 1 and nod like receptor protein 3 in placenta tissues of pregnant women with preeclampsia |
| The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan Province, 471003 |
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Abstract To investigate the expressions and clinical significances of silent information regulator 1 (SIRT1)and nod like receptor protein 3 (NLRP3)in placenta tissues of pregnant women with preeclampsia (PE). Methods: The expressions of SIRT1 and NLRP3 in paraffin sections of placenta tissues of 80 pregnant women with PE were detected by immunohistochemical method. 40 women with early-onset PE were in group A, and 40 women with late-onset PE were in group B. Another 40 normal pregnant women were selected in group C. Results: The positive rates of the SIRT1 expression in placenta tissues of the women in group A, group B, and group C were 12.5%, 35%, and 92.5%, respectively, and which had significantly different among the three groups (χ2=54.71, P<0.05). The positive rates of the NLRP3 expression in placenta tissues of the women in group A, group B, and group C were 95%, 72.5%, and 30%, respectively, and which had significantly different among the three groups (χ2=38.75, P<0.05). The expression level of SirT1 in placental tissues of the women with PE was negatively correlated with their NLRP3 level in placental tissues (r=-0.60, P<0.05). Conclusion: The low expression of SIRT1 and the high expression of NLRP3 in placenta tissues of the women may promote the occurrence and development of their PE, and both SIRT1 and NLRP3 may involve in the occurrence and development of PE.
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