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| Value of Toll-like receptor 4 signaling pathway for predicting the occurrence of unexplained recurrent spontaneous abortion of women with polycystic ovary syndrome |
| Nanyang City Central Hospital, Henan Province, 473000 |
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Abstract To explore the value of Toll- like receptor 4 (TLR4)signaling pathway for predicting the occurrence of unexplained recurrent spontaneous abortion (URSA)of women with polycystic ovary syndrome (PCOS). Methods: 92 women with PCOS complicating URSA were collected in study group and another 50 women with PCOS and normal pregnancy were collected in control group from October 2019 to January 2022. The mRNA expression levels of TLR4 and nuclear factorKappa B (NF-kB)of the women were compared between two groups. Multivariate logistic regression model was used to analyze the factors affecting the occurrence of PCOS and URSA of the women. Spearman's correlation test was used to the correlative analysis. Receiver operating characteristic (ROC)curve was used to evaluate the efficacy of the TLR4 and NF-kB mRNA levels of the women for predicting their PCOS and URSA. Results: The body mass index (BMI)value, and the rates of alcohol consumption, smoking, and insulin resistance, and the mRNA levels of TLR4 and NF-kB of the women in the study group were significantly higher than those of the women in the control group (P＜0.05). Multivariate logistic regression analysis showed that BMI, drinking, smoking, insulin resistance, and the TLR4 and NF-kB mRNA levels of the women were all the influencing factors of their PCOS complicating URSA (P＜0.05). Correlation analysis indicated that the mRNA levels of TLR4 and NF-kB of the women were positively correlated with their PCOS and URSA occurrence (r=0.474, 0.511, all P＜0.001). ROC analysis showed that the predictive efficacy (AUC=0.792)of the combined levels of TLR4 and NF-kB mRNA of the women for their PCOS and URSA occurrence was significantly higher than that of the TLR4 mRNA level or NF-kB mRNA level alone, and the sensitivity, the specificity, and the critical value of which were 80.4%, 74.0%, and 2.6, respectively. Conclusion: TLR4 signaling pathway of the women with URSA is closely related to their occurrence of PCOS, the molecules TLR4 and NF-kB related with this pathway are the influencing factors of PCOS complicating URSA, and the TLR4 and NF-kB levels have good predictive efficacy for PCOS complicating URSA.
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