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| Effects of metformin combined with insulin aspart for treating women with gestational diabetes mellitus on their blood glucose control and pregnancy outcomes |
| 1.Qinhuangdao Maternal and Child Health Care Hospital, Qinhuangdao, Hebei Province, 06600；2.The First Hospital of Qinhuangdao |
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Abstract To study the effects of metformin combined with insulin aspart for treating pregnant women with gestational diabetes mellitus (GDM) on their blood glucose control and pregnancy outcomes. Methods: A total of 97 pregnant women with GDM were divided into group A (48 cases) and group B (49 cases) according to random number table method from March 2018 to September 2020. The women in group A were treated with subcutaneous injection of insulin aspart, and the women in group B were treated with metformin combined with insulin aspart. The levels of blood glucose indicators, adipokines, the inflammatory factors, and the pregnancy outcomes of the women were compared between the groups. Results: After treatment, the levels of fasting blood glucose, 2h postprandial blood glucose, glycosylated hemoglobin, endolipins, leptin, interleukin-6, interleukin-1, and tumor necrosis factor-α of the women in the two groups had decreased significantly, and which of the women in group B were significantly lower than those of the women in group A (P<0.05). The levels of adiponectin and omentin Ⅰ of the women in the two groups had increased significantly after treatment, and which of the women in group B were significantly higher than those of the women in group A (P<0.05). The incidences of cesarean section (12.2%), macronesia (4.1%), neonatal hypoglycemia (2.0%), and fetal respiratory distress (6.1%) of the women in group B were significantly lower than those (31.3%, 16.7%, 12.5%, and 20.8%) of the women in group A (all P<0.05). Conclusion: Metformin combined with insulin aspart for treating pregnant women with GDM can help to effectively control their blood glucose level, can decrease their levels of adipokines and inflammatory factors, and can improve their pregnancy outcomes.
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