Abstract To investigate the value of serum pregnancy-associated plasma protein A (PAPP-A) combined with ultrasonography examination of pregnant women for diagnosing placental abruption early. Methods: The clinical data of 157 pregnant women with high risk factors from January 2018 to January 2021 were selected in this study, which included 112 cases without placental abruption in group A and 45 cases were with placental abruption in group B. The expression level of serum PAPP-A of the women in the two groups was detected by enzyme-linked immunosorbent assay, and the placenta situation of the women in the two groups was examined by color Doppler ultrasonography. Receiver operator characteristic (ROC) curve was used to analyze the values of PAPP-A level and ultrasonography examination of pregnant women for diagnosing their placental abruption. The consistency of clinical results was determined by Kappa test. Results: The expression level of serum PAPP-A of the women in group B was significantly lower than that of the women in group A (P＜0.05). The area under curve, the specificity, the sensitivity, and the cut-off value of the serum PAPP-A level of the women for diagnosing their placental abruption were 0.899, 95.5%, 73.3%, and 3.88 U/L, respectively. The sensitivity, the specificity, and the negative predictive value of the serum PAPP-A level combined with ultrasonography examination for diagnosing their placental abruption were 93.3%, 93.6%, and 97.2%, respectively, which were significantly higher than those of the serum PAPP-A level or ultrasonography examination alone (all P＜0.05). The consistency between the ultrasonography examination and serum PAPP-A level of the women for diagnosing their placental abruption and their clinical results were higher and extremely high (Kappa=0.758, 0.848, all P＜0.05). The proportion of stillbirth, uterine placental apoplexy, and postpartum hemorrhage of the women, and low body weight infants in group B were significantly higher than those in group A (P＜0.05). Conclusion: Ultrasound examination combined with the level of serum PAPP-A of the pregnant women can improve the
clinical detection efficacy of their placental abruption.
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