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| Predictive value of the levels of serum chitinase 3-like protein 1 and suppressor of cytokine signaling 3 for gestational diabetes mellitus during the first trimester of pregnancy |
| The First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, 066000 |
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Abstract To explore the predictive value of the levels of serum chitinase 3-like protein 1 (CHI3L1) and suppressor of cytokine signaling 3 (SOCS3) levels for gestational diabetes mellitus (GDM) of pregnant women during the first trimester of pregnancy. Methods: A total of 340 pregnant women who underwent pregnancy examinations were selected as the research subjects from June 2019 to June 2021. Based on the results of 75g glucose tolerance test (OGTT) administered orally for these women during 24-28 gestational weeks, the women were divided into group A (100 women with GDM) and group B (240 healthy pregnant women). The serum CHI3L1 and SOCS3 levels of the women in the two groups during the first trimester of pregnancy were detected by enzyme-linked immunosorbent assay, and which of the women were compared between the two groups. Pearson correlation analysis was used to investigate the relationship between the serum CHI3L1 and SOCS3 levels of the women during the first trimester of pregnancy and their levels of fasting blood glucose and fasting insulin (FINS), and their homeostasis model assessment of insulin resistance (HOMA-IR). Receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the serum CHI3L1 and SOCS3 levels during the first trimester of pregnancy for GDM. Multivariate logistic regression analysis was used to analyze the related factors of GDM occurrence. Results: The levels of serum CHI3L1 (115.62±20.11 pg/ml) and SOCS3 (2.36±0.55 mg/ml) of the women in group A were significantly higher than those (22.25±6.24 pg/ml and 0.63±0.12 mg/ml) of the women in group B (all P＜0.05). In group A, the serum CHI3L1 and SOCS3 levels of the women were positively correlated with the levels of their fasting blood glucose and FINS, and their HOMA-IR value (all P＜0.05). ROC curve showed that the area under the curve, the cut-off value, the sensitivity, and the specificity of the serum CHI3L1 level of the women during the first trimester of pregnancy for predicting their GDM were 0.768, 78.4pg/ml, 93.0%, and 54.3%, respectively. The area under the curve, the cut-off value, the sensitivity, and the specificity of the serum SOCS3 level of the women during the first trimester of pregnancy for predicting their GDM were 0.831, 1.2mg/ml, 93.0%, and 67.1%, respectively. The area under the curve, the sensitivity, and the specificity of the combination of serum CHI3L1 and SOCS3 levels of the women during the first trimester of pregnancy for predicting their GDM were 0.920, 87.0%, and 85.0%, respectively. Multivariate analysis showed that serum CHI3L1 level (OR 4.10, 95%CI 1.92-8.78) and serum SOCS3 level (OR 3.93, 95%CI 2.01-7.68) of the women during the first trimester of pregnancy were the risk factors of their GDM concurrence (all P＜0.05). Conclusion: The serum CHI3L1 and SOCS3 levels of the women during the first trimester of pregnancy increase, and both of which are the independent influencing factors of the occurrence of GDM and have certain predictive value for the occurrence of GDM.
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