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Abstract To study the value of magnetic resonance imaging (MRI) and transvaginal ultrasound combined with the levels of carbohydrate antigen (CA) 724 and human epididymis secretory protein 4 (HE4) for diagnosing ovarian cancer. Methods: 146 patients with benign or malignant ovarian tumors from September 2018 to September 2021 were analyzed retrospectively. These patients all had undergone vaginal ultrasonography and MRI, and their serum HE4 and CA724 levels were detected by chemiluminescence method. According to the postoperative pathological examination as the standard, these patients were divided into group A (70 patients with benign tumors) and group B (76 patients with malignant tumors). The diagnostic value of transvaginal ultrasound and MRI combined with the serum CA724 and HE4 levels of the patients for their ovarian cancer was analyzed. Results: The serum levels of CA724 (16.65±3.07 U/ml) and HE4 (176.06±23.42 pmol/L) of the patients in group B were significantly higher than those (7.32±1.72 U/ml and 74.85±13.67 pmol/L) of the patients in group A (all P＜0.05). The accuracy, the sensitivity, and the specificity of the HE4 level of the patients for diagnosing their ovarian cancer were 84.9%, 85.7%, and 84.2%, respectively. The accuracy, the sensitivity, and the specificity of the CA72 level of the patients for diagnosing their ovarian cancer were4 were 84.3%, 82.9%, and 84.5%, respectively. The accuracy, the sensitivity, and the specificity of the transvaginal ultrasound of the patients for diagnosing their ovarian cancer were 85.6%, 84.3%, and 98.9%, respectively. The accuracy, the sensitivity, and the specificity of MRI value of the patients for diagnosing their ovarian cancer were 90.4%, 92.9%, and 88.2%, respectively. The accuracy, the sensitivity, and the specificity of transvaginal ultrasound and MRI combined with the serum CA724 and HE4 levels of the patients for diagnosing their ovarian cancer were 90.4%, 97.1%, and 84.2%, respectively. Conclusion: MRI and transvaginal ultrasound combined with the serum CA724 and HE4 levels of the patients for diagnosing their ovarian cancer is better than MRI, transvaginal ultrasound, the serum CA724 level, or the HE4 level alone.
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