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| Influence factors of subseguent pregnancy outcomes after treatment of uterine fibroids by high intensity focused ultrasound |
| Sichuan Provincial Maternity and Child Health Care Hospital，Chengdu, Sichuan Province, 610031 |
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Abstract To analyze the pregnancy status of women after treatment of uterine fibroids by high intensity focused ultrasound (HIFU), and to study the affecting factors of the pregnancy outcomes of the women. Methods: 220 women with uterine fibroids who wanted pregnancy and had received HIFU treatment from April 2019 to May 2020 were selected retrospectively. These women were followed up for 2 years after treatment by HIFU. The pregnancy and delivery status of these women were recorded. The related factors affecting the pregnancy outcomes of these women were analyzed. Results: There were 148 (67.3%) women with successful pregnancy within 2 years after HIFU treatment, which included 135 women with natural pregnancy and 13 women with pregnancy by assisted reproductive technology. Among 148 women with successful pregnancy, there were 89 (60.1%) cases with delivered, which included 26 cases of vaginal delivery and 63 cases of cesarean section. There were 6 cases with postpartum hemorrhage, 4 cases with uterine compression suture hemostasis, and 2 cases with total hysterectomy. There were 59 cases with abnormal delivery, which included 39 cases with spontaneous abortion and 20 cases with termination of pregnancy due to ectopic pregnancy and placental insufficiency. There were no significant differences in the body mass index (BMI) value, the disease duration, the fibroid type, the maximum diameter of fibroids, the average diameter of fibroids, the fibroid location, and the irradiation power, the irradiation time, and the fibroid ablation rate after HIFU treatment between the women with normal delivery and the women without normal delivery (P＞0.05). There were significant differences in the age, the infertility history, the fibroid volume, and the number of fibroids between the women with normal delivery and the women without normal delivery (P＜0.05). Logistic regression model showed that advanced age, history of infertility, and large size of fibroids of the women were the independent influencing factors of their successful pregnancy and delivery after HIFU treatment (P＜0.05). Conclusion: The successful pregnancy rate of the women in 2 years after uterine fibroids operation by HIFU is high, and the pregnancy outcomes of the women are good. The factors affecting of pregnancy outcomes of these women should be paid attention to in clinic.
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