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| Analysis of the value of amplitude-integrated electroencephalogram combined with neonatal neurological and behavioral assessment for neonatal brain development of pregnant women with gestational diabetes mellitus |
| Suzhou Integrated Traditional Chinese and Western Medicine Hospital, Suzhou, Jiangsu Province, 215000 |
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Abstract To explore the value of amplitude-integrated electroencephalogram electroencephalogram (aEEG)combined with neonatal neurological and behavioral assessment (NBNA)for neonatal brain development of pregnant women with gestational diabetes mellitus (GDM). Methods: A total of 280 neonates of the pregnant women with GDM who delivered in hospital were selected in research group, and 280 neonates of healthy pregnant women were selected in control group from October 2018 to March 2021. The aEEG monitor and NBNA were conducted on the neonates in both groups after birth, and the evaluative values of aEEG and NBNA for neonatal brain development were analyzed. Results: The aEEG abnormalities rate (43 cases, 15.4%)of the neonates in the research group were significantly higher than that (16 cases, 5.7%)of the neonates in the control group. The individual scores of general response, behavioral ability, passive muscle tone, active muscle tone, original reflex, and the total NBNA score of the neonates in research group were significantly lower than those of the neonates in the control group. The abnormal rate of NBNA measurement (17.5%)of the neonates in the research group was significantly higher than that of the neonates in the control group (all P＜0.05). There was no significant difference in the coincidence rate of aEEG monitor and NBNA (95.7% vs.96.4%)between the two groups (P＞0.05). The area under curve (AUC)of aEEG and NBNA for evaluating the neonatal brain development were 0.808 and 0.824, with the sensitivity of 89.4% and 90.2%, and the specificity of 70.7% and 74.6%, respectively. The AUC of the aEEG combined with NBNA for assessing the neonatal brain development was 0.972, with the sensitivity of 98.3% and the specificity of 92.3%. Conclusion: The abnormal incidence of neonatal brain development of the pregnant women GDM increases. The brain development of newborns can be evaluated by aEEG and NBNA as early as possible. The combined of aEEG and NBNA for evaluating neonatal brain development has the best value, and the abnormal result of which should be paid attention to in clinic.
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