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Abstract To analyze the image feature of foramen ovale restriction or closure(FO-R/C)of fetus by prenatal echocardiography and to explore the value of prenatal echocardiography for diagnosing fetal FO-R/C. Methods: 80 pregnant women diagnosed as fetal FO-R/C by prenatal echocardiography were selected in case group, and 80 pregnant women with healthy fetuses were selected in control group from January 2018 to January 2020. The heart cavity size, such as right atrium(RA), right ventricle(RV), left atrium(LA), and left ventricle(LV), the inner diameter of main pulmonary artery(MPA), aortic(AO), foramen ovale(FO), the velocity aortic valve(VAO)and the pulmonary valve(VMPA)over the blood flow, and velocity foramen ovale(VFO)of maximum flow of the fetuses were measured by echocardiography. The clinical data of the women in the two groups were analyzed. Receiver operating characteristic curve(ROC)was used to analyze the diagnostic efficacy of the ultrasonic parameters for FO-R/C of the fetuses. Results: In the case group, there were 72 cases diagnosed as fetal FO-R, the average diameter of FO of the fetuses was 2.25±0.31mm, and there were 8 cases diagnosed as fetal FO-C. The findings of prenatal echocardiography included 60(75.0%)cases with the increase of RA and the decrease of left ventricular ratio of fetus, 44(55.0%)cases with atrial septal tumor of fetus, 56(70.0%)cases with varying degrees of tricuspid regurgitation of fetus, and 8(10.0%)cases with pericardial effusion. In the case group, 80 children were reexamined by transthoracic echocardiography again on the day of birth, all of them were confirmed to be FO-R/C, and the coincidence rate with prenatal diagnosis was 100.0%. There were significant differences in the values of RV/LV, RA/LA, MPA/AO, VMPA/VAO, FO/AO, and FO/RA of the fetus between the two groups(P＜0.05). ROC analysis showed that the values of RV/LV, RA/LA, MPA/AO, VMPA/VAO, and FO/RA were all the effective indicators for diagnosing fetal FO-R/C, and the areas under the curve of which were 0.933, 0.900, 0.838, 0.708, and 0.593, respectively. Conclusion: Prenatal echocardiography has high diagnostic value for fetal FO-R/C, and it can closely monitor the intrauterine situation of the fetus, which can guide the clinical practice of taking effective measures for improving the prognosis of FO-R/C of the fetuses.
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