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| Effects of Bushen jianpi huayu method combined with drospirenone and ethinylestradiol tablets for treating patients with polycystic ovary syndrome of kidney deficiency and blood stasis type on their TCM syndromes and ovarian function |
| West China Guang'an Hospital of Sichuan University, Guang'an, Sichuan Province, 638000 |
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Abstract To explore the effects of Bushen jianpi huayu method combined with drospirenone and ethinylestradiol tablets for treating patients with polycystic ovary syndrome(PCOS)of kidney deficiency and blood stasis type on their TCM syndromes and ovarian function. Methods: 104 patients with PCOS of kidney deficiency and blood stasis type were selected and were randomly divided into control group and observation group(52 cases in each group)from January 2019 to January 2021. The patients in the control group were treated with drospirenone and ethinylestradiol tablets for 3 menstrual cycles, and the patients in the observation group were given Bushen jianpi huayu method on the basis of the medication of the control group additionally for 3 menstrual cycles. The scores of TCM syndromes of the patients before and after treatment were compared between the two groups, and the efficacy for TCM syndromes of the patients in the two groups was evaluated. The results by B ultrasound examination, such as the number of follicles, the endometrial thickness and the ovarian volume, and levels of sex hormones, such as luteinizing hormone(LH), testosterone(T), LH/follicle stimulating hormone(FSH), reproductive hormones anti-Müllerian hormone(AMH), inhibin B(IHNB), leptin(LP), and adiponectin(ADPN)of the patients before and after treatment were compared between the two groups. The menstrual recovery and ovulation recovery of the patients in the two groups were observed, and the adverse reactions of the patients in the two groups were evaluated. Results: After treatment, the TCM syndrome scores of the patients in the two groups had decreased significantly, and which of the patients in the observation group were significantly lower than those of the patients in the control group. The total effective rate of TCM syndrome(92.3%)of the patients in the observation group was significantly higher than that(76.9%)of the patients in the control group(all P＜0.05). The number of follicles, the ovarian volume, the endometrial thickness, the levels of serum LH, T, AMH, and LP, and LH/FSH value of the patients in the two groups had decreased significantly, the ADPN level of the patients in the two groups had increased significantly, and the range of changes of which of the patients in the observation group were significantly more than those of the patients in the control group(all P＜0.05). The recovery rates of menstruation and ovulation(86.5% and 78.9%)of the patients in the observation group were significantly higher than those(67.3% and 59.6%)of the patients in the control group(all P＜0.05). There was no any patient with obvious adverse reactions in the two groups. Conclusion: Bushen jianpi huayu method combined with drospirenone and ethinylestradiol tablets for treating the patients with PCOS of kidney deficiency and blood stasis type can significantly reduce their TCM syndromes scores, enhance their efficacy of TCM syndromes, effectively improve the ovarian reserve function, regulate the levels of sex hormones, down-regulate the level of their serum LP level, promote their ADPN level, and promote their menstrual recovery and ovulation recovery, with high safety in clinical application.
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