Abstract To explore the changes of the levels of blood lipopolysaccharide binding protein (LBP), secretory phospholipase A2 (sPLA2), and interleukin 8 (IL-8) of pregnant women, and to study their values for diagnosing the premature rupture of membranes complicated with intrauterine infection of the women. Methods: The clinical data of 98 pregnant women with premature rupture of membranes complicated with intrauterine infection (in group A), 50 pregnant women with simple premature rupture of membranes (in group B), and 60 healthy pregnant women who underwent pregnancy examination (in group C) from January 2020 to January 2021 were collected retrospectively. The changes of the levels of serum LBP, sPLA2, and IL-8 of the women in the three groups were analyzed. The diagnostic value of LBP, sPLA2, and IL-8 levels of the women for their premature rupture of membranes complicated with intrauterine infection was also analyzed. Results: The levels of LBP, sPLA2, and IL-8 of the women in group C were 70.54±20.65 ng/ml, 74.58±20.41 ng/ml, and 7.84±0.80 pg/ml, respectively, those of the women in group B were 82.56±24.59 ng/ml, 121.25±26.04 ng/ml, and 11.48±1.38 pg/ml, respectively, and those of the women in group A were 107.43±30.35 ng/ml, 150.22±25.41 ng/ml, 15.76±1.67 pg/ml, respectively. The levels of LBP, sPLA2, and IL-8 of the women in group C, in group B, and in group A had increased gradually, and which of the women without full term of pregnancy in group A were significantly higher than those of the women with full term of pregnancy (all P＜0.05). Receiver operating characteristic curve analysis showed that the area under the curve (AUC), the sensitivity, the specificity, and the cut-off value of the serum LBP level of the women for diagnosing their premature rupture of membranes complicated with intrauterine infection were 0.797, 75.5%, 78.5%, and 89.56ng/ml, respectively. The AUC, the sensitivity, the specificity, and the cut-off value of the serum sPLA2 level of the women for diagnosing their premature rupture of membranes complicated with intrauterine infection were 0.839, 76.7%, 79.9%, and 107.84ng/ml, respectively. The AUC, the sensitivity, the specificity, and the cut-off value of the serum IL-8 level of the women for diagnosing their premature rupture of membranes complicated with intrauterine infection were 0.995, 85.3%, 86.6%, and 9.15 pg/ml, respectively. The AUC, the sensitivity, the specificity, and the accuracy of the combined of the levels of serum LBP, sPLA2, and IL-8 of the women for diagnosing their premature rupture of membranes complicated with intrauterine infection were 0.998, 91.5%, 93.1%, and 95.5%, respectively, which were all significantly higher than those of the serum LBP level, sPLA2 level, or IL-8 level alone (P＜0.05). Conclusion: The expressions levels of blood LBP, sPLA2, and IL-8 of the pregnant women with the premature rupture of membranes complicated with intrauterine infection increase abnormally. The combined of the levels of serum LBP, sPLA2, and IL-8 of the women for diagnosing their premature rupture of membranes complicated with intrauterine infection has higher value.
|
