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| Effects of dehydroepiandrosterone for adjuvant therapy of different age patients with low ovarian reserve on their related indexes after in-vitro fertilization embryo transplantation |
1.The Second Affiliated Hospital of Air Force Military Medical University, Xi’an, Shaanxi Province, 710038;
2.Sichuan Baoshihua Hospital |
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Abstract To explore the effects of dehydroepiandrosterone (DHEA) for adjuvant therapy of different age patients with low ovarian reserve (DOR) on their endometrial receptivity and the parameters of in-vitro fertilization-embryo transplantation (IVF-ET). Methods: The clinical data of 135 patients with DOR who had undergone IVF-ET assisted fertility treatment from May 2018 to July 2020 were analyzed retrospectively. These patients were treated with DHEA and were divided into group A (42 patients aged in <35 Years old), group B (45 patients aged in 35-40 years old), and group C (36 patients aged in >40 years old) according to the different age of the patients. The baseline data of the patients was compared among the three groups. The endometrial thickness, the values of pulsatility index (PI) and resistance index (RI), the gonadotropin (Gn) dosage, the Gn used days, the number of eggs obtained, the insemination number, the cleavage number, and the high-quality embryo numbers of the patients in the three groups after treatment were evaluated. The rates of implantation, clinical pregnancy, early miscarriage, multiple pregnancy, and ectopic pregnancy of the patients in the three groups were observed. Results: There were no significant differences in the body mass index value, the duration of infertility, the cause of infertility, the thickness of the endometrial thickness, the values of PI and RI, the number of eggs obtained, the insemination number, the cleavage number, and the high-quality embryo number of the patients before treatment among the three groups (P＞0.05). There were no significant differences in the Gn dosage, the Gn used days, and the rates of early miscarriage, multiple pregnancy, ectopic pregnancy, implantation, clinical pregnancy of the patients after treatment among the three groups (P＞0.05). The endometrial thickness (15.12±2.32mm), the number of eggs obtained (4.16±0.69), the insemination number (3.18±0.52), the cleavage number (2.39±0.38), and the high-quality embryo number (1.45±0.28), and the rates of implantation (46.3%) and clinical pregnancy (45.2%) of the patients in group A were significantly higher than those of the patients in group B and C, but the values of PI (1.75±0.32) and RI (0.68±0.11) of the patients in group A were significantly lower than those of the patients in group B and C (P＜0.05). Conclusion: The improved ovarian reserve function and endometrial receptivity of the patients <35 years old after DHEA for adjuvant therapy are better than those of the patients >35 years old.
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