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| Efficacy of high-intensity focused ultrasound combined with chemoradiotherapy and Chinese medicine for treating patients with advanced cervical cancer |
| Chengde Hospital of Traditional Chinese Medicine, Chengde, Hebei Province, 067000 |
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Abstract To observe the efficacy of high-intensity focused ultrasound (HIFU) combined with taxel and cisplatin (TP) chemotherapy and Chinese medicine for treating patients with cervical cancer above IIb stage. Methods: 60 patients with cervical cancer above IIb stage were selected and were randomly divided into two groups (30 cases in each group) according to the random number table from August 2018 to February 2021. The patients in the two groups were treated with TP chemotherapy combined with traditional Chinese medicine therapy. On this basis, the patients in the observation group were given HIFU therapy additionally. The effective rate, the MR apparent diffusion coefficient (ADC), the maximum tumor diameter, and the serum tumor marker levels, such as carcinoembryonic antigen (CEA), carbohydrate antigen 125(CA125), and squamous cell carcinoma antigen (SCC-Ag), of the patients in 1, 3, and 6 months after treatment were compared between the two groups. Results: The effective rate (83.3%) of the patients in the observation group was significantly higher than that (56.7%) of the patients in the control group (P＜0.05). The ADC values of the patients in the two groups after treatment were significantly higher than those before treatment. The maximum diameter of the tumor of the patients after treatment was significantly lower than that before treatment. The ADC value of the patients in the observation group in 1, 3, or 6 months after treatment (0.99±0.10×10-3mm2/s, 1.17±0.12×10-3mm2/s, or 1.39±0.14×10-3mm2/s) was significantly higher than those (0.92±0.09×10-3mm2/s, 1.06±0.10×10-3mm2/s, or 6.39±0.23×10-3mm2/s) of the patients in the control group . The maximum diameter of tumor of the patients in 1, 3, or 6 months after treatment (3.52±0.15cm, 3.31±0.14cm, or 3.12±0.13cm) was significantly lower than that (3.94±0.1cm6, 3.82±0.15cm, or 3.55±0.14cm) of the patients in the control group (all P＜0.05). The serum levels of CEA, CA125, and SCC-Ag of the patients in the two groups after treatment had decreased significantly, and which of the patients in 1, 3, and 6 months after treatment in the observation group were significantly lower than those of the patients in the control group (all P＜0.05). During the treatment, there were patients in both groups with adverse reactions, such as abdominal pain and diarrhea, leukopenia, hemoglobin reduction, and neutropenia, but the rate of which of the patients had no significant difference between the two groups (P＞0.05). The proportion of nausea and vomiting (13.3%) of the patients in the observation group was significantly lower than that (36.7%) of the patients in the control group (P＜0.05). Conclusion: HIFU combined with TP chemoradiotherapy and traditional Chinese medicine therapy for treating patients with advanced cervical cancer over IIb staging can effectively reduce their level of tumor markers and can inhibit the growth of their tumor foci with definite clinical effect, and which can reduce the proportion of their nausea and vomiting during treatment.
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