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Abstract To investigate the effects of single injection of dexmedetomidine (Dex) during laparoscopic hysterectomy of patients on their observer's assessment of alertness/sedation (OAA/S) score and their restlessness in recovery period. Methods: 70 patients who wanted laparoscopic hysterectomy were selected and were divided into three groups by random number table from January 2018 to December 2021. 23 patients in group A were given continuous pump injection of Dex 0.3 μg/(kg·h) from 15 minutes before induction of anesthesia to 20 minutes at the end of the operation, 24 patients in group B were given single intravenous injection of Dex 0.6 μg/kg before induction of anesthesia, and 23 patients in group C were given conventional general anesthesia. The heart rate (HR), mean arterial pressure (MAP), OAA/S score, rate of adverse reactions during recovery period, extubation time, orientation recovery time, and staying time in the anesthesia recovery room of the patients were compared among the three groups. Results: The HR value of the patients in group A and group C at T1 (immediately after abdominal pressure reached 10mmHg), T2 (5min), T3 (10min), T4 (20min), and T5 (40min) were significantly higher than those at T0 (before pneumoperitoneum establishment). The HR value of the patients in group B, group A, and group C at T0, T1, T2, T3, T4 and T5 had increased gradually (all P＜0.05). The MAP value of the patients in the three groups at T1, T2, T3, T4, and T5 was significantly higher than that of the patients at T0. The MAP value of the patients in group B, group A, and group C at T0, T1, T2, T3, T4, and T5 had increased gradually (all P＜0.05). The score of OAA/S of the patients in group B or group A was significantly better than that of the patients in group C (P＜0.05). The total incidence of adverse reaction (8.3%) of the patients in group B was significantly lower than that (39.1%) of the patients in group A or that (56.5%) of the patients in group C. The extubation time (14.02±2.54 min), the directional force recovery time (18.24±6.05 min), and the stay time in anesthesia recovery room (22.56±7.48 min) of the patients in group B were significantly shorter than those (23.12±3.05 min, 24.75±8.19 min, 26.84±8.89 min) of the patients in group A or those (19.33±2.86 min, 20.18±6.67 min, 34.37±11.13 min) of the patients in group C (all P＜0.05). Conclusion: Single injection of Dex during laparoscopic total hysterectomy of the patients has better anesthetic effect, which can stabilize their hemodynamic indicators, shorten their recovery time of anesthesia, improve their quality during anesthesia recovery period, and reduce their occurrence of adverse reactions during the recovery period.
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