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| Meta-analysis of the correlation between estrogen receptor β gene polymorphism and male infertility |
| Jiangsu Health Development Research Center, National Health and Family Planning Commission Contraceptives Adverse Reaction Surveillance Center, Nanjing, Jiangsu Province, 210036 |
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Abstract To evaluate the correlation between gene polymorphisms in rs1256049 and rs4986938 sites of estrogen receptor β (ERβ) and male infertility. Methods: The related literatures were retrieved from CNKI, Pubmed, Wanfang, and so on. State software was used for statistical analysis. Results: This meta-analysis included 11 articles on rs1256049 site of 1914 infertility and 2012 healthy males, and 10 articles on rs4986938 SNP site of 2136 infertility and 2257 healthy males. For the rs1256049 site of ERβ, there was significant correlation between gene AG and gene GG (OR=1.35, 95%CI: 1.01-1.80), which suggested that gene polymorphisms in rs1256049 site of ERβof males was correlation with their infertility. The subgroup analysis based on different race and genotyping methods showed that the models of A compared with G (OR=2.47, 95%CI:1.37-4.44), AG compared with GG (OR=2.51, 95%CI 1.34-4.72), and AA + AG compared with GG (OR=2.55, 95%CI 1.38-4.73) suggested that gene polymorphisms in rs4986938 site of ERβof males increased risks the infertility of Caucasian males. There were no significant different among 5 comparison models of gene in rs4986938 site of ERβ. In the subgroup analysis according to the genotyping methods, the gene AG compared with GG (OR=0.48, 95%CI 0.24-0.94) suggested that decreased risk of male infertility. Conclusion: Gene rs1256049 site of ERβmay be a susceptible site of male infertility, while AG genotype of rs4986938 site of ERβ may reduce the risk of male infertility.
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